Recent Advances on the Use of Structural Biology for the Design of Novel Envelope Immunogens of HIV-1

Shi-Hua      Xiang

doi:10.2174/1570162X113116660053

Abstract

Many efforts have been made in the worldwide quest for a prophylactic HIV vaccine to end the AIDS pandemic, but none has yet succeeded. The lessons learned have repeatedly informed us that the traditional or conventional approaches directly using the pathogens or subunits will not be sufficient for an effective HIV/AIDS vaccine. Recent advances in structure-based technology have shown some promise in the quest for a better immunogen in HIV vaccine development. According to the basic binding structural relationship of an antigen and an antibody, structurebased antigen design could bring some hope for the development of an effective vaccine against HIV.

Keywords: Antibody epitope, envelope trimer, germline B-cells, HIV-1, immunogen design, structure-based design, vaccine development.

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Current HIV Research

Title:Recent Advances on the Use of Structural Biology for the Design of Novel Envelope Immunogens of HIV-1

Volume: 11 Issue: 6

Author(s): Shi-Hua Xiang

Affiliation:

Keywords: Antibody epitope, envelope trimer, germline B-cells, HIV-1, immunogen design, structure-based design, vaccine development.

Abstract: Many efforts have been made in the worldwide quest for a prophylactic HIV vaccine to end the AIDS pandemic, but none has yet succeeded. The lessons learned have repeatedly informed us that the traditional or conventional approaches directly using the pathogens or subunits will not be sufficient for an effective HIV/AIDS vaccine. Recent advances in structure-based technology have shown some promise in the quest for a better immunogen in HIV vaccine development. According to the basic binding structural relationship of an antigen and an antibody, structurebased antigen design could bring some hope for the development of an effective vaccine against HIV.

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Cite this article as:

Xiang Shi-Hua, Recent Advances on the Use of Structural Biology for the Design of Novel Envelope Immunogens of HIV-1, Current HIV Research 2013; 11 (6) . https://dx.doi.org/10.2174/1570162X113116660053

DOI https://dx.doi.org/10.2174/1570162X113116660053	Print ISSN 1570-162X
Publisher Name Bentham Science Publisher	Online ISSN 1873-4251

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