Paracetamol-Induced Fixed Drug Eruption at an Unusual Site

Title:Paracetamol-Induced Fixed Drug Eruption at an Unusual Site

Volume: 7 Issue: 3

Author(s): Carmen Gómez-Traseira, Patricia Rojas-Pérez-Ezquerra, Leticia Sánchez-Morillas, Rosario González- Mendiola, María Rubio-Pérez, Alicia Moral-Morales and José JulioLaguna-Martinez

Affiliation:

Keywords: Allergy, fixed drug eruption, paracetamol.

Abstract: Background: Paracetamol (acetaminophen) is a widely used analgesic/antipyretic drug for which hypersensitivity reactions appear to be increasingly frequent. Objective: We report the case of a woman who experienced several delayed selective reactions induced by paracetamol: fixed drug eruptions (FDEs) with typical features but an unusual distribution (hard palate and a maculopapular rash. Methods: Skin tests: prick, intradermal and patch tests as well as a single-blind oral challenge test (OCT) were performed. Results: Skin tests were negative. The OCT was necessary to confirm the diagnosis. Interestingly, the challenge test elicited an FDE-type lesion instead of a maculopapular rash. Conclusions: Our findings could reflect 2 different clinical patterns of delayed allergic reactions, or, more probably, the initial phase of a unique clinical entity that was stopped by the corticosteroids prescribed during the challenge. However, we were unable to confirm these hypotheses. The uncommon anatomical site of the lesions (hard palate) is noteworthy. Some relevant patents are also summarized in this paper.

Cite this article as:

Gómez-Traseira Carmen, Rojas-Pérez-Ezquerra Patricia, Sánchez-Morillas Leticia, González- Mendiola Rosario, Rubio-Pérez María, Moral-Morales Alicia and JulioLaguna-Martinez José, Paracetamol-Induced Fixed Drug Eruption at an Unusual Site, Recent Patents on Inflammation & Allergy Drug Discovery 2013; 7 (3) . https://dx.doi.org/10.2174/1872213X113079990018