Recent Approaches in Design of Peptidomimetics for Antimicrobial Drug Discovery Research

Title:Recent Approaches in Design of Peptidomimetics for Antimicrobial Drug Discovery Research

Volume: 13 Issue: 7

Author(s): Sandeep Lohan and Gopal Singh Bisht

Affiliation:

Keywords: Cationic antimicrobial peptides, Antibiotics resistance, Synthetic mimics of antimicrobial peptides (SMAMPs), Peptidomimetics.

Abstract: Resistant pathogenic microbial strains are emerging at a rate that far exceeds the pace of new anti-infective drug development. In order to combat resistance development, there is pressing need to develop novel class of antibiotics having different mechanism of action in comparison to existing antibiotics. Antimicrobial peptides (AMPs) have been identified as ubiquitous components of innate immune system and widely regarded as a potential source of future antibiotics owing to a remarkable set of advantageous properties ranging from broad spectrum of activity to low propensity of resistance development. However, AMPs present several drawbacks that strongly limit their clinical applicability as ideal drug candidates such as; poor bioavailability, potential immunogenicity and high production cost. Thus, to overcome the limitations of native peptides, peptidomimetic becomes an important and promising approach. The different research groups worldwide engaged in antimicrobial drug discovery over the past decade have paid tremendous effort to design peptidomimetics. This review will focus on recent approaches in design of antimicrobial peptidomimetics their structure–activity relationship studies, mode of action, selectivity & toxicity.

Cite this article as:

Lohan Sandeep and Singh Bisht Gopal, Recent Approaches in Design of Peptidomimetics for Antimicrobial Drug Discovery Research, Mini-Reviews in Medicinal Chemistry 2013; 13 (7) . https://dx.doi.org/10.2174/1389557511313070010