Targets of Anti-glucocorticoid Therapy for Stress-related Diseases

Title:Targets of Anti-glucocorticoid Therapy for Stress-related Diseases

Volume: 8 Issue: 1

Author(s): Antonio Martocchia, Manuela Stefanelli, Giulia M Falaschi, Lavinia Toussan, Massimiliano Rocchietti March, Silvia Raja, Gloria Romano and Paolo Falaschi

Affiliation:

Keywords: Corticosteroid, HPA axis, glucocorticoid receptor, stress.

Abstract: The stress response during chronic conditions increases vulnerability to diseases through the activation of adaptive systems, in particular, the hypothalamus-pituitary-adrenal (HPA) axis. Dysregulation in HPA activity (central and peripheral) has been reported in chronic diseases, like metabolic syndrome, type-2 diabetes mellitus, atherosclerosis-related disease, essential hypertension, dementia, depression, particularly during comorbid conditions.

Different targets of anti-glucocorticoid treatment have been proposed, acting at supra-hypothalamic, HPA axis, glucocorticoid receptor and post-receptor levels. The recent promising patents on the therapy against glucocorticoid-mediated damage will be presented and discussed.

Cite this article as:

Martocchia Antonio, Stefanelli Manuela, Falaschi M Giulia, Toussan Lavinia, March Rocchietti Massimiliano, Raja Silvia, Romano Gloria and Falaschi Paolo, Targets of Anti-glucocorticoid Therapy for Stress-related Diseases, Recent Patents on CNS Drug Discovery (Discontinued) 2013; 8 (1) . https://dx.doi.org/10.2174/1574889811308010007