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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Gluten-dependent Intestinal Autoimmune Response

Author(s): Ilma Rita Korponay-Szabo, Zsofia Simon-Vecsei, Luigina De Leo and Tarcisio Not

Volume 18, Issue 35, 2012

Page: [5753 - 5758] Pages: 6

DOI: 10.2174/138161212803530826

Price: $65

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Abstract

Celiac disease is a multi-systemic autoimmune disease of the small bowel induced by gluten in genetically predisposed subjects. Highly specific and gluten-dependent production of auto-antibodies targeting self-proteins of the transglutaminase family occurs in the intestinal mucosa. These anti-transglutaminase antibodies are found deposited in intestinal and extra-intestinal tissue where they might exert biological effects, together with the intestinal mucosal gliadin-specific T lymphocytes. We conducted a brief review on antitransglutaminase antibodies effects, discussing their roles in the pathogenesis of several clinical manifestations of celiac disease.

Keywords: Genetic gluten intolerance, intestinal anti-transglutaminase antibodies, auto-immunity


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