Sinonasal Carcinoma: Updated Phenotypic and Molecular Characterization

Title:Sinonasal Carcinoma: Updated Phenotypic and Molecular Characterization

Volume: 8 Issue: 3

Author(s): Diana Bell and Ehab Y. Hanna

Affiliation:

Keywords: Sinonasal carcinoma, Phenotype, Genome analysis, Targeted therapy

Abstract: The most commonly encountered carcinoma of the sinonasal tract is the keratinizing/ non-keratinizing squamous cell carcinoma. However, this complex anatomic location may represent the site of other epithelial malignant neoplasms of varying histogenesis. These tumors are clinically aggressive and often fatal; historically, treatment outcomes have been poor. Differentiating these tumor types may have clinical impact as advances in therapeutic intervention could increase survival, quality of life and occasionally result in a cure. This review focuses on recent advances in the molecular and phenotypic characterization of sinonasal carcinomas and their impact on diagnosis and treatment.

Cite this article as:

Bell Diana and Y. Hanna Ehab, Sinonasal Carcinoma: Updated Phenotypic and Molecular Characterization, Current Cancer Therapy Reviews 2012; 8 (3) . https://dx.doi.org/10.2174/157339412802653137