A RhoA-Derived Peptide Inhibits Human Immunodeficiency Virus-1 Entry In Vitro

Maciej      Maselko; Casey      Ward; Manoj      Pastey

doi:10.2174/157016211794582605

Abstract

RhoA-derived peptides have been shown to have antiviral activity against both human respiratory syncytial virus and human parainfluenza virus-3. The present study investigates the toxicity, anti-HIV-1 activity and mechanism of action of a RhoA-derived peptide (RhoA 77-95). The efficacy of this peptide was compared to a scrambled peptide of the same amino acid composition and Enfuvirtide, a HIV entry inhibitor. Our data show that this RhoA-derived peptide is a non-toxic and effective inhibitor of a CXCR4 tropic strain of HIV-1. We also demonstrate that the mechanism of entry inhibition is likely mediated by polyanionic properties and is dependent on the dimerization of peptides.

Keywords: Antiviral, HIV-1, Peptides, RhoA

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Current HIV Research

Title: A RhoA-Derived Peptide Inhibits Human Immunodeficiency Virus-1 Entry In Vitro

Volume: 9 Issue: 1

Author(s): Maciej Maselko, Casey Ward and Manoj Pastey

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Keywords: Antiviral, HIV-1, Peptides, RhoA

Abstract: RhoA-derived peptides have been shown to have antiviral activity against both human respiratory syncytial virus and human parainfluenza virus-3. The present study investigates the toxicity, anti-HIV-1 activity and mechanism of action of a RhoA-derived peptide (RhoA 77-95). The efficacy of this peptide was compared to a scrambled peptide of the same amino acid composition and Enfuvirtide, a HIV entry inhibitor. Our data show that this RhoA-derived peptide is a non-toxic and effective inhibitor of a CXCR4 tropic strain of HIV-1. We also demonstrate that the mechanism of entry inhibition is likely mediated by polyanionic properties and is dependent on the dimerization of peptides.

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Cite this article as:

Maselko Maciej, Ward Casey and Pastey Manoj, A RhoA-Derived Peptide Inhibits Human Immunodeficiency Virus-1 Entry In Vitro, Current HIV Research 2011; 9 (1) . https://dx.doi.org/10.2174/157016211794582605

DOI https://dx.doi.org/10.2174/157016211794582605	Print ISSN 1570-162X
Publisher Name Bentham Science Publisher	Online ISSN 1873-4251

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