Ghrelin: A Gastric Peptide that Regulates Hypothalamic Control of Feeding

Title: Ghrelin: A Gastric Peptide that Regulates Hypothalamic Control of Feeding

Volume: 3 Issue: 3

Author(s): H. Yamaguchi, M. Nakazato and K. Kangawa

Affiliation:

Keywords: Ghrelin

Abstract: Ghrelin, a novel growth-hormone-releasing peptide isolated from human and rat stomach, is a 28-amino acid peptide with a posttranslational acylation modification that is indispensable for its activity. Ghrelin stimulates secretion of growth hormone, food intake, and body weight gain. This review will focus on the discovery, structural characteristics, tissue distribution, and physiological functions of ghrelin, as well as the regulation of its expression and secretion. Future directions of clinical application of ghrelin as an anabolic peptide are discussed.

Cite this article as:

Yamaguchi H., Nakazato M. and Kangawa K., Ghrelin: A Gastric Peptide that Regulates Hypothalamic Control of Feeding, Current Medicinal Chemistry - Central Nervous System Agents 2003; 3 (3) . https://dx.doi.org/10.2174/1568015033477758