The New Immunosuppression: Intervention at the Dendritic Cell-T-Cell Interface

Title: The New Immunosuppression: Intervention at the Dendritic Cell-T-Cell Interface

Volume: 5 Issue: 4

Author(s): A. M. Paterson, S. F. Yates, K. F. Nolan and H. Waldmann

Affiliation:

Keywords: Dendritic cells, T cells, immunological synapse, antibodies, pharmacological agents, tolerance

Abstract: Dendritic cells (DCs) play an important role in initiating and directing T-cells towards immunity or tolerance. An important aim of emerging immunosuppressive strategies is to ensure that antigen is perceived in a tolerogenic context. This would have obvious benefit in minimising the need for long-term drug maintenance in organ transplantation, hypersensitivity and autoimmune diseases. Here we review the biology of the interplay between the DC and T-cell, with a specific focus on therapeutic drugs targeting molecules that effect their interaction and function.

Cite this article as:

Paterson M. A., Yates F. S., Nolan F. K. and Waldmann H., The New Immunosuppression: Intervention at the Dendritic Cell-T-Cell Interface, Current Drug Targets - Immune, Endocrine & Metabolic Disorders 2005; 5 (4) . https://dx.doi.org/10.2174/1568005310505040397