Abstract
Intractable epilepsy can have a detrimental impact on children, increasing the likelihood of developmental delays and cognitive dysfunction, and negatively impacting quality of life. The goals of surgical intervention in pediatric epilepsy are multifactorial and include optimal seizure control and/or remission, improvement of functionality, and facilitation of brain development. Several factors contribute to post-surgical outcomes in children, which will be discussed in this article. Research findings suggest that surgical treatment can have a positive effect beyond seizure control, including improvements in cognition, academic skills, neurobehavioral functioning, and emotional state. An important emerging theme in the presented studies is advocacy for early surgical intervention in children. Future expansion of research in long-term pediatric surgery outcomes is necessary, especially regarding epilepsy in posterior brain regions, effect on academic performance, and impact on overall quality of life following surgery. Advances in structural and functional neuroimaging will contribute to greater understanding of the relationship between outcomes and plasticity.
Keywords: Cognitive, epilepsy, neuropsychology, pediatric, psychosocial, outcomes, surgery
Current Pediatric Reviews
Title: Pediatric Epilepsy Surgery: Neuropsychological and Psychosocial Outcomes
Volume: 8 Issue: 1
Author(s): Jacqueline Phillips-Sabol, Daniel Cruz-Laureano, Anna E. Pineda-Olvera, Bethany Williams and J. Gregory Westhafer
Affiliation:
Keywords: Cognitive, epilepsy, neuropsychology, pediatric, psychosocial, outcomes, surgery
Abstract: Intractable epilepsy can have a detrimental impact on children, increasing the likelihood of developmental delays and cognitive dysfunction, and negatively impacting quality of life. The goals of surgical intervention in pediatric epilepsy are multifactorial and include optimal seizure control and/or remission, improvement of functionality, and facilitation of brain development. Several factors contribute to post-surgical outcomes in children, which will be discussed in this article. Research findings suggest that surgical treatment can have a positive effect beyond seizure control, including improvements in cognition, academic skills, neurobehavioral functioning, and emotional state. An important emerging theme in the presented studies is advocacy for early surgical intervention in children. Future expansion of research in long-term pediatric surgery outcomes is necessary, especially regarding epilepsy in posterior brain regions, effect on academic performance, and impact on overall quality of life following surgery. Advances in structural and functional neuroimaging will contribute to greater understanding of the relationship between outcomes and plasticity.
Export Options
About this article
Cite this article as:
Phillips-Sabol Jacqueline, Cruz-Laureano Daniel, E. Pineda-Olvera Anna, Williams Bethany and Gregory Westhafer J., Pediatric Epilepsy Surgery: Neuropsychological and Psychosocial Outcomes, Current Pediatric Reviews 2012; 8 (1) . https://dx.doi.org/10.2174/157339612799746290
DOI https://dx.doi.org/10.2174/157339612799746290 |
Print ISSN 1573-3963 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6336 |
Call for Papers in Thematic Issues
Early-life nutrition: impacts on health and diseases
In early life, organs and hormonal axes are especially susceptible to changes that can affect the intestinal mucosa, immune system, and long-term health. Critical factors in the developmental process, including maternal diet, type of delivery, breastfeeding, and the nutritional status of mothers and children, have gained prominence. Evidence suggests that ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
A Salicylic Acid-Based Analogue Discovered from Virtual Screening as a Potent Inhibitor of Human 20α-Hydroxysteroid Dehydrogenase
Medicinal Chemistry Physiological Roles of Neuronal Nicotinic Receptors Subtypes: New Insights on the Nicotinic Modulation of Neurotransmitter Release, Synaptic Transmission and Plasticity
Current Topics in Medicinal Chemistry Clinical Utility of Neuronal Cells Directly Converted from Fibroblasts of Patients for Neuropsychiatric Disorders: Studies of Lysosomal Storage Diseases and Channelopathy
Current Molecular Medicine Gabapentin for the Treatment of Cancer-Related Pain Syndromes
Reviews on Recent Clinical Trials Activators and Inhibitors of the Ion Channel of the NMDA Receptor
Current Drug Targets Prediction of Disease-Related Genes Based on Hybrid Features
Current Proteomics Positron Emission Tomography and Brain Monoamine Neurotransmission - Entries for Study of Drug Interactions
Current Pharmaceutical Design Folate Status and Depressive Symptoms in Reproductive-Age Women
Current Nutrition & Food Science FMRI of the Emotions: Towards an Improved Understanding of Amygdala Function
Current Medical Imaging Role of ABC Transporters in the Chemoresistance of Human Gliomas
Current Cancer Drug Targets Recent Advances in Synthesis and Biological Applications of Substituted Ureas
Current Organic Chemistry Do ATP-Binding Cassette Transporters Cause Pharmacoresistance in Epilepsy? Problems and Approaches in Determining which Antiepileptic Drugs are Affected
Current Pharmaceutical Design Persons with Co-Existing Neurological Disorders: Risk Analysis, Considerations and Management in COVID-19 Pandemic
CNS & Neurological Disorders - Drug Targets 3D Printing Technology in Pharmaceutical Manufacturing and Drug Delivery Application
Current Pharmaceutical Design Relevance of Breast Cancer Resistance Protein to Brain Distribution and Central Acting Drugs: A Pharmacokinetic Perspective
Current Drug Metabolism P2Y Receptors: Focus on Structural, Pharmacological and Functional Aspects in the Brain
Current Medicinal Chemistry Subject Index to Volume 3
Current Drug Targets - CNS & Neurological Disorders Synthesis, Anticonvulsant and Binding Interaction Study of Novel Piperamides with Bovine Serum Albumin by Fluorescence Spectroscopy
Central Nervous System Agents in Medicinal Chemistry Neuroprotective Properties of Peroxisome Proliferator-Activated Receptor Alpha (PPARα) and its Lipid Ligands
Current Medicinal Chemistry Competitive Gly/NMDA Receptor Antagonists
Current Topics in Medicinal Chemistry