Mitochondria: The Common Upstream Driver of Amyloid-β and Tau Pathology in Alzheimers Disease

Title: Mitochondria: The Common Upstream Driver of Amyloid-β and Tau Pathology in Alzheimers Disease

Volume: 8 Issue: 5

Author(s): D. F.F. Silva, A. R. Esteves, C. R. Oliveira and S. M. Cardoso

Affiliation:

Keywords: Alzheimer's disease, amyloid-β, autophagy, microtubule network, mitochondria, tau, calcium homeostasis, oxidative phosphorylation, AD development, oxidative stress markers, neurodegeneration, mitochondrial integrity, resonance spectroscopy

Abstract: Mitochondrial dysfunction has been widely implicated in the etiology of Alzheimers disease (AD). Evidence shows a mitochondrial-mediated impairment of autophagy that potentiates amyloid-β (Aβ) deposition. Accordingly, recent data obtained from AD models, in which mitochondrial alterations are a prominent feature, demonstrated abnormalities in microtubule network, involving tubulin and tau post-translational modifications. In this review we will discuss mitochondrial- regulated processes where mitochondrial malfunction is likely to start a sequence of events leading to sirtuin- 2 activation, microtubule network breakdown, and impairment of the autophagic pathway. Because sirtuin-2 activity depends on cellular NAD+ availability, mitochondrial regulation of NAD+ levels may contribute to an increase in sirtuinmediated tubulin deacetylation. A vicious cycle become installed which potentiates tau hyperphosphorylation, together with Aβ overproduction and deposition. Overall, targeting microtubule network constitutes a promising strategy for pharmacological therapy in AD.

Cite this article as:

F.F. Silva D., R. Esteves A., R. Oliveira C. and M. Cardoso S., Mitochondria: The Common Upstream Driver of Amyloid-β and Tau Pathology in Alzheimers Disease, Current Alzheimer Research 2011; 8 (5) . https://dx.doi.org/10.2174/156720511796391872