Hematopoietic Stem Cells: Source Matters

Title: Hematopoietic Stem Cells: Source Matters

Volume: 3 Issue: 4

Author(s): Richard L. Haspel and Kenneth B. Miller

Affiliation:

Keywords: Bone marrow transplant, hematopoietic stem cell transplant, cord blood transplant, peripheral blood stem cell transplant

Abstract: Bone marrow, peripheral blood and cord blood are all sources of hematopoietic stem cells for allogeneic transplants. These sources differ in regard to collection methods, cellular content and transplant outcomes. In the related setting, use of peripheral blood stem cells, when compared to bone marrow, results in faster engraftment and may confer a survival benefit in advanced disease but also may lead to an increase in chronic graft-versus-host-disease. While cord blood stem cells are the simplest to collect and allow the greatest flexibility in HLA matching, they contain the lowest stem cell dose leading to the slowest engraftment. In this review, we discuss the advantages and disadvantages of these different stem cell sources as well as areas for further research.

Cite this article as:

Haspel L. Richard and Miller B. Kenneth, Hematopoietic Stem Cells: Source Matters, Current Stem Cell Research & Therapy 2008; 3 (4) . https://dx.doi.org/10.2174/157488808786734033