Abstract
The growth factor signals regulate the balance of cell proliferation and cell death to maintain the homeostasis in vivo; hence, deregulation of the balance underlies a variety of human diseases. The PI3K-Akt network is activated by various cytokines or growth factors and mediates intracellular signals to regulate a wide variety of cellular responses, including anti-apoptosis, proliferation, cell cycling, protein synthesis, glucose metabolism, and telomere activity. Genomic mutations, alterations, amplifications, and/or translocations of the oncogenes, tumor suppressor genes, or kinases involved in the PI3K-Akt regulatory network underlie various human diseases such as cancers, viral infections, glucose intolerance (or diabetes mellitus), schizophrenia, and/or autoimmune diseases. Therefore, targeting the PI3K-Akt network becomes an attractive goal for drug development.This review article summarizes the current knowledge about the regulation of the PI3K-Akt signaling network to highlight therapeutic implications for human diseases.
Keywords: Phosphoinositide 3 Kinase, PI3K-Akt network, Akt, inhibitors, pharmacological compounds, cancer therapy
Current Signal Transduction Therapy
Title: Regulation of the PI3K-Akt Network: Current Status and a Promise for the Treatment of Human Diseases
Volume: 3 Issue: 2
Author(s): Masayuki Noguchi, Toshiyuki Obata and Futoshi Suizu
Affiliation:
Keywords: Phosphoinositide 3 Kinase, PI3K-Akt network, Akt, inhibitors, pharmacological compounds, cancer therapy
Abstract: The growth factor signals regulate the balance of cell proliferation and cell death to maintain the homeostasis in vivo; hence, deregulation of the balance underlies a variety of human diseases. The PI3K-Akt network is activated by various cytokines or growth factors and mediates intracellular signals to regulate a wide variety of cellular responses, including anti-apoptosis, proliferation, cell cycling, protein synthesis, glucose metabolism, and telomere activity. Genomic mutations, alterations, amplifications, and/or translocations of the oncogenes, tumor suppressor genes, or kinases involved in the PI3K-Akt regulatory network underlie various human diseases such as cancers, viral infections, glucose intolerance (or diabetes mellitus), schizophrenia, and/or autoimmune diseases. Therefore, targeting the PI3K-Akt network becomes an attractive goal for drug development.This review article summarizes the current knowledge about the regulation of the PI3K-Akt signaling network to highlight therapeutic implications for human diseases.
Export Options
About this article
Cite this article as:
Noguchi Masayuki, Obata Toshiyuki and Suizu Futoshi, Regulation of the PI3K-Akt Network: Current Status and a Promise for the Treatment of Human Diseases, Current Signal Transduction Therapy 2008; 3 (2) . https://dx.doi.org/10.2174/157436208784223189
DOI https://dx.doi.org/10.2174/157436208784223189 |
Print ISSN 1574-3624 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-389X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Glucocorticoids in Pregnancy
Current Pharmaceutical Biotechnology Editorial The Role of Mesenchymal Stem Cells in Bone Regeneration: Underlying Mechanisms and Systemic Regulatory Factors
Current Stem Cell Research & Therapy Genes, Environment, Intermediate Phenotypes, and the Pathogenesis of Diabetic Nephropathy
Current Pharmacogenomics subject Index To Volume 2
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents Functional Genomics of Cardioprotection by Ischemic Conditioning and the Influence of Comorbid Conditions: Implications in Target Identification
Current Drug Targets Programming Apoptosis and Autophagy with Novel Approaches for Diabetes Mellitus
Current Neurovascular Research Clinical, Molecular, and Genetic Characteristics of PAPA Syndrome: A Review
Current Genomics Statins and Solid Organ Transplantation
Current Pharmaceutical Design Drug Development from Natural Resource: A Systematic Approach
Mini-Reviews in Medicinal Chemistry Dynamics of Telomere Length in Different Age Groups in a Latvian Population
Current Aging Science Abdominal Aortic Aneurysm: What About Screening?
Current Pharmaceutical Design The VHL Tumor Suppressor: Master Regulator of HIF
Current Pharmaceutical Design Nanomedicine against Alzheimer’s and Parkinson’s Disease
Current Pharmaceutical Design Synthetic Strategies for the Construction of δ-Carbolines: A Chemical Ladder in Search of Novel Drugs
Current Organic Synthesis Optimal Treatment of Severe Community-Acquired Pneumonia
Current Respiratory Medicine Reviews Adenosine Myocardial Perfusion Imaging
Current Medical Imaging Mimicking Microvascular Alterations of Human Diabetic Retinopathy: A Challenge for the Mouse Models
Current Medicinal Chemistry Comparison of Salivary Antioxidants and Oxidative Stress Status in Gestational Diabetes Mellitus and Healthy Pregnant Women
Endocrine, Metabolic & Immune Disorders - Drug Targets A Possible Placental Factor for Preeclampsia: sFlt-1
Current Medicinal Chemistry Primary and Secondary Prevention Trials in Alzheimer Disease: Looking Back, Moving Forward
Current Alzheimer Research