Activity of Amidine-containing Diphenylureas Against P. falciparum

Title: Activity of Amidine-containing Diphenylureas Against P. falciparum

Volume: 2 Issue: 2

Author(s): Guatam Bhattacharya, Lucia Gerena, Suping Jiang and Karl A. Werbovetz

Affiliation:

Keywords: diamidine, antimalarial, plasmodium falciparum, plasmepsin, heme assembly

Abstract: Amidine-containing derivatives of the diphenylurea antimalarial lead compound WR268961, a putative plasmepsin inhibitor, were prepared and tested against erythrocyte-stage P. falciparum. Diamidine 8 was the most active compound, displaying IC50 values of 54 nM and 41 nM versus chloroquine sensitive (D6) and chloroquine resistant (W2) parasites, respectively.

Cite this article as:

Bhattacharya Guatam, Gerena Lucia, Jiang Suping and Werbovetz A. Karl, Activity of Amidine-containing Diphenylureas Against P. falciparum, Letters in Drug Design & Discovery 2005; 2 (2) . https://dx.doi.org/10.2174/1570180053175061