Cyclodextrins Based Enantioselective, Potentiometric Membrane Electrodes (EPME) and their Applications for Enantioanalysis of L-Cysteine in Urine

Title: Cyclodextrins Based Enantioselective, Potentiometric Membrane Electrodes (EPME) and their Applications for Enantioanalysis of L-Cysteine in Urine

Volume: 7 Issue: 4

Author(s): Raluca-Ioana Stefan-van Staden, Luxolo Holo and Jacobus F. van Staden

Affiliation:

Keywords: L-cysteine, Cyclodextrin, Direct potentiometry, Enantioanalysis, Potentiometric Selectivity Coefficient, PVP, D-Cys, Liquid chromatography, Chemiluminescence, Capillary electrophoresis

Abstract: Four enantioselective, potentiometric membrane electrodes based on carbon paste impregnated with α-, β-, 2- hydroxyl-3-trimethylammoniopropyl -β- (as chloride salt) and γ-cyclodextrins are proposed for the enantioanalysis of Lcysteine. The proposed electrodes exhibited near-Nernstian slopes in a wide linear concentration range: 10-10 - 10-3 mol/L, with very low detection limits, near 10-11 mol/L. The surfaces of the electrodes are easily renewable by simply polishing on an alumina paper.

Cite this article as:

Stefan-van Staden Raluca-Ioana, Holo Luxolo and F. van Staden Jacobus, Cyclodextrins Based Enantioselective, Potentiometric Membrane Electrodes (EPME) and their Applications for Enantioanalysis of L-Cysteine in Urine, Current Pharmaceutical Analysis 2011; 7 (4) . https://dx.doi.org/10.2174/157341211797457998