Progress in the Development of Bestatin Analogues as Aminopeptidases Inhibitors

L.      Chen; Y.      Teng; W.      Xu

doi:10.2174/092986711794940879

Abstract

Aminopeptidases play essential roles in protein maturation, activation, and stability as well as in the degradation and regulation of hormonal and nonhormonal peptides that can serve as important enzyme targets for drug design. This review will focus on an effective inhibitor of aminopeptidases, bestatin, including work to find better inhibitors in the past three decades that has sought to optimize bestatin and prospective developments in bestatin optimization in the future.

Keywords: Aminopeptidases, analogues, bestatin, optimization, nonhormonal peptides, Enzymes, hydrolysis, pathological disorders, hypertension, inflammation, neurodegeneration, leukemias