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CNS & Neurological Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5273
ISSN (Online): 1996-3181

Review Article

Noninvasive Therapies: A Forthcoming Approach to Parkinson's Treatment

Author(s): Umer Anayyat, Faiza Ahad, Bushra Muhammad Fordil, Hajra Hameed, Mengqing Li, Qinyao Yu, Yunpeng Wei and Xiaomei Wang*

Volume 24, Issue 3, 2025

Published on: 02 September, 2024

Page: [165 - 180] Pages: 16

DOI: 10.2174/0118715273318429240812094557

Price: $65

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Abstract

In this review, we have discussed the invasive and non-invasive treatment options for Parkinson’s Disease (PD) following their safety, specificity, and reliability. Initially, this study has highlighted the invasive treatment options and the side effects they possess. A deep understanding of L-Dopa treatment, as oral or infusion, and the use of dopamine agonists has indicated that there is a need to acquire an alternative treatment for PD. The combined therapy with L-Dopa has been proven to affect PD, but with some limitations, such as mild to chronic side effects, with particular requirements of age and health of the patient and a large amount of expenditure. In the discussion of noninvasive methods to treat PD, we have found that this approach is comparatively slow and requires repetitive sessions, but is safe, effective, and reliable at any stage of PD. Electroconvulsive therapy has revealed its effectiveness in various neurological diseases, including PD. Transcranial current stimulation (direct or alternative) has already been shown to have an alleviative response to PD symptoms. Transcranial magnetic stimulations and other strategies of using the magnetic field for potential treatment options for PD need to be explored further imminently.

Keywords: Parkinson's disease treatment, non-invasive neurotherapies, L-Dopa efficacy, side effects, transcranial magnetic stimulation, electroconvulsive therapy.

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