Abstract
A practical and novel approach for the regioselective synthesis of 3-arylthioindole derivatives has been accomplished using a combination of indole substrates with p-toluene sulfonyl hydrazide. This methodology employs NIS as the oxidant and PPh3 as the reductant to give the desired 3-arylthioindoles in good to excellent yields. This method offers several advantages, including simplicity, operational ease, and broad substrate scope.
Keywords: Indole, sulfonyl hydrazide, indole thioether, thiolation, regioselective, 3-arylthioindoles.
Current Organic Chemistry
Title:Regioselective Thiolation of Indole to Construct 3-Arylthioindoles
Volume: 29 Issue: 2
Author(s): Ashvani Yadav, Rohit Kumar, Vikas Yadav, Mitushree Ghosh and Virendra Prasad*
Affiliation:
- Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi, UP, 221005, India
Keywords: Indole, sulfonyl hydrazide, indole thioether, thiolation, regioselective, 3-arylthioindoles.
Abstract: A practical and novel approach for the regioselective synthesis of 3-arylthioindole derivatives has been accomplished using a combination of indole substrates with p-toluene sulfonyl hydrazide. This methodology employs NIS as the oxidant and PPh3 as the reductant to give the desired 3-arylthioindoles in good to excellent yields. This method offers several advantages, including simplicity, operational ease, and broad substrate scope.
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Cite this article as:
Yadav Ashvani, Kumar Rohit, Yadav Vikas, Ghosh Mitushree and Prasad Virendra*, Regioselective Thiolation of Indole to Construct 3-Arylthioindoles, Current Organic Chemistry 2025; 29 (2) . https://dx.doi.org/10.2174/0113852728313866240807175713
DOI https://dx.doi.org/10.2174/0113852728313866240807175713 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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