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Current Microwave Chemistry

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ISSN (Print): 2213-3356
ISSN (Online): 2213-3364

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Mini-Review Article

Green Synthesis of Thiazoles and Thiadiazoles having Anticancer Activities under Microwave Irradiation

Author(s): Sasadhar Majhi*, Piyali Mitra and Pankaj Kumar Mondal

Volume 11, Issue 2, 2024

Published on: 18 July, 2024

Page: [74 - 94] Pages: 21

DOI: 10.2174/0122133356325646240715074628

Price: $65

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Abstract

Sulfur and nitrogen-containing heterocycles have received a great deal of attention due to their unique structures and therapeutic relevance. Thiazoles and thiadiazoles are important fivemembered heterocycles containing sulfur and nitrogen atoms that draw the special attention of researchers due to their synthetic diversity and potent pharmacological properties. Thiazoles and thiadiazoles are used in agrochemicals, liquid crystals, sensors, the cosmetic industry, cyanine dyes, etc. Sometimes, organic synthesis, including thiazoles and thiadiazoles syntheses with the help of conventional methods, is laborious work, while synthesis of promising organic molecules using microwave irradiation provides better yields, diminishes the reaction time, and reduces unwanted side products. The major causes of death worldwide are due to cancer. Current research demands the design and preparation of novel compounds, including thiazoles and thiadiazoles, that may help to combat cancer, as chemotherapy or chemo drugs suffer from some demerits, including toxicity, lack of selectivity, resistance, and side effects. Hence, the review focuses on the microwave-assisted synthesis of thiazoles and thiadiazoles as a sustainable technique for the first time, and it also aims to highlight the anticancer activities of thiazoles and thiadiazole derivatives elegantly.

Keywords: Bioactive heterocycles, thiazoles, thiadiazoles, microwave irradiation, sustainable chemistry, cytotoxicity, medicinal impact.

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