Deciphering the Correlation between the Emergence of Lung Carcinoma
Associated with Tuberculosis-related Inflammation

Prashant      Chauhan; Pratibha      Pandey; Seema      Ramniwas; Fahad      Khan; Ramish      Maqsood

doi:10.2174/0118715303301146240522095638

Abstract

Lung cancer and tuberculosis (TB) are classified as the second-most life-threatening diseases globally. They both are exclusively represented as major public health risks and might exhibit similar symptoms, occasionally diagnosed simultaneously. Several epidemiological studies suggest that TB is a significant risk factor for the progression of lung cancer. The staggering mortality rates of pulmonary disorders are intrinsically connected to lung cancer and TB. Numerous factors play a pivotal role in the development of TB and may promote lung carcinogenesis, particularly among the geriatric population. Understanding the intricacies involved in the association between lung carcinogenesis and TB has become a crucial demand of current research. Consequently, this study aims to comprehensively review current knowledge on the relationship between tuberculosis-related inflammation and the emergence of lung carcinoma, highlighting the impact of persistent inflammation on lung tissue, immune modulation, fibrosis, aspects of reactive oxygen species, and an altered microenvironment that are linked to the progression of tuberculosis and subsequently trigger lung carcinoma.

Keywords: Lung cancer, tuberculosis (TB), chronic inflammation, immune checkpoint inhibitors (ICIs), reactive oxygen species (ROS), pulmonary disorders.

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Endocrine, Metabolic & Immune Disorders - Drug Targets

Title:Deciphering the Correlation between the Emergence of Lung Carcinoma Associated with Tuberculosis-related Inflammation

Volume: 25 Issue: 4

Author(s): Prashant Chauhan, Pratibha Pandey*, Seema Ramniwas, Fahad Khan and Ramish Maqsood

Affiliation:

Department of Biotechnology, Noida Institute of Engineering and Technology, Greater Noida, Uttar Pradesh, India
Center for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India

Keywords: Lung cancer, tuberculosis (TB), chronic inflammation, immune checkpoint inhibitors (ICIs), reactive oxygen species (ROS), pulmonary disorders.

Abstract: Lung cancer and tuberculosis (TB) are classified as the second-most life-threatening diseases globally. They both are exclusively represented as major public health risks and might exhibit similar symptoms, occasionally diagnosed simultaneously. Several epidemiological studies suggest that TB is a significant risk factor for the progression of lung cancer. The staggering mortality rates of pulmonary disorders are intrinsically connected to lung cancer and TB. Numerous factors play a pivotal role in the development of TB and may promote lung carcinogenesis, particularly among the geriatric population. Understanding the intricacies involved in the association between lung carcinogenesis and TB has become a crucial demand of current research. Consequently, this study aims to comprehensively review current knowledge on the relationship between tuberculosis-related inflammation and the emergence of lung carcinoma, highlighting the impact of persistent inflammation on lung tissue, immune modulation, fibrosis, aspects of reactive oxygen species, and an altered microenvironment that are linked to the progression of tuberculosis and subsequently trigger lung carcinoma.

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Chauhan Prashant, Pandey Pratibha*, Ramniwas Seema, Khan Fahad and Maqsood Ramish, Deciphering the Correlation between the Emergence of Lung Carcinoma Associated with Tuberculosis-related Inflammation, Endocrine, Metabolic & Immune Disorders - Drug Targets 2025; 25 (4) . https://dx.doi.org/10.2174/0118715303301146240522095638

DOI https://dx.doi.org/10.2174/0118715303301146240522095638	Print ISSN 1871-5303
Publisher Name Bentham Science Publisher	Online ISSN 2212-3873

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