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Review Article

Effect of Rotenone on the Neurodegeneration among Different Models

Author(s): Iqra Subhan and Yasir Hasan Siddique*

Volume 25, Issue 8, 2024

Published on: 02 May, 2024

Page: [530 - 542] Pages: 13

DOI: 10.2174/0113894501281496231226070459

Price: $65

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Abstract

Rotenone is a naturally occurring plant product used as an insecticide, pesticide and piscicide. It is lipophilic in nature and can cross the blood-brain barrier and induce the degeneration of neurons. It inhibits the mitochondrial respiratory chain complex I and stops the transfer of electrons. It induces ROS generation, which impairs mitochondrial activity. Rotenone is a toxic agent which causes the death of neurons. The present review describes the effect of rotenone on neurodegeneration with an emphasis on behavioral, pathological and neuropathological components carried out on various experimental models such as cell lines, Drosophila melanogaster, mice and rats.

Keywords: Rotenone, insecticide, complex-i inhibitor, neurodegeneration, cell lines, Drosophila, mice, rats.

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