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Mini-Reviews in Medicinal Chemistry

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ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

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Mini-Review Article

Schiff Bases: A Captivating Scaffold with Potential Anticonvulsant Activity

Author(s): Rakesh Sahu* and Kamal Shah*

Volume 24, Issue 18, 2024

Published on: 16 April, 2024

Page: [1632 - 1650] Pages: 19

DOI: 10.2174/0113895575302197240408121537

Price: $65

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Abstract

One of the most important organic compounds, also known as a Schiff base, imine, or azomethine, has been associated with several biological processes. The group is a component of both natural or synthetic chemicals and functions as both a precursor and an intermediary in the synthesis of therapeutically active substances. The review highlights the various non-metal Schiff bases' structure-activity relationship (SAR) studies, general model, docking, and design approach for anticonvulsant actions. Schiff bases serve as linkers in numerous synthetic compounds with a variety of activities, according to the findings of several investigations. As a result, the current review will give readers a thorough understanding of the key ideas put forth by different researchers regarding the anticonvulsant properties of Schiff bases. It will serve as a valuable information source for those planning to synthesize new anticonvulsant molecules that contain Schiff bases as pharmacophores or biologically active moieties.

Keywords: Schiff bases, anticonvulsant agents, epilepsy, imines, GABA, structure-activity relationships (SAR).

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