Solid CaCO₃ Formation in Glioblastoma Multiforme and its Treatment with Ultra-Nanoparticulated NPt-Bionanocatalysts

Title:Solid CaCO₃ Formation in Glioblastoma Multiforme and its Treatment with Ultra-Nanoparticulated NPt-Bionanocatalysts

Volume: 25 Issue: 3

Author(s): Tessy López-Goerne*, Alfonso Arellano, Francisco J. Padilla-Godínez, Carlos Magaña, Antonela González-Bondani and Rafael Valiente

Affiliation:

• Department of Health Care, Nanotechnology and Nanomedicine Laboratory, Metropolitan Autonomous University, Xochimilco, Mexico City, 04960, Mexico

Keywords: Bionanocatalyst, Pt/TiO₂, NPt, glioblastoma multiforme, CaCO3, catalytic nanomedicine.

Abstract:

Background: Glioblastoma multiforme (GBM), the most prevalent form of central nervous system (CNS) cancer, stands as a highly aggressive glioma deemed virtually incurable according to the World Health Organization (WHO) standards, with survival rates typically falling between 6 to 18 months. Despite concerted efforts, advancements in survival rates have been elusive. Recent cutting-edge research has unveiled bionanocatalysts with 1% Pt, demonstrating unparalleled selectivity in cleaving C-C, C-N, and C-O bonds within DNA in malignant cells. The application of these nanoparticles has yielded promising outcomes.

Objective: The objective of this study is to employ bionanocatalysts for the treatment of Glioblastoma Multiforme (GBM) in a patient, followed by the evaluation of obtained tissues through electronic microscopy.

Methods: Bionanocatalysts were synthesized using established protocols. These catalysts were then surgically implanted into the GBM tissue through stereotaxic procedures. Subsequently, tissue samples were extracted from the patient and meticulously examined using Scanning Electron Microscopy (SEM).

Results and Discussion: Detailed examination of biopsies via SEM unveiled a complex network of small capillaries branching from a central vessel, accompanied by a significant presence of solid carbonate formations. Remarkably, the patient subjected to this innovative approach exhibited a three-year extension in survival, highlighting the potential efficacy of bionanocatalysts in combating GBM and its metastases.

Conclusion: Bionanocatalysts demonstrate promise as a viable treatment option for severe cases of GBM. Additionally, the identification of solid calcium carbonate formations may serve as a diagnostic marker not only for GBM but also for other CNS pathologies.

Cite this article as:

López-Goerne Tessy*, Arellano Alfonso, Padilla-Godínez J. Francisco, Magaña Carlos, González-Bondani Antonela and Valiente Rafael, Solid CaCO₃ Formation in Glioblastoma Multiforme and its Treatment with Ultra-Nanoparticulated NPt-Bionanocatalysts, Current Cancer Drug Targets 2025; 25 (3) . https://dx.doi.org/10.2174/0115680096289012240311023133