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Current Alzheimer Research

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Review Article

Research Progress of Mitophagy in Alzheimer's Disease

Author(s): Jinglin Yao, Bohong Kan*, Zhengjia Dong and Zhenyu Tang

Volume 20, Issue 12, 2023

Published on: 12 March, 2024

Page: [827 - 844] Pages: 18

DOI: 10.2174/0115672050300063240305074310

Price: $65

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Abstract

The prevalence of Alzheimer's disease (AD) is increasing as the elderly population, which hurts elderly people's cognition and capacity for self-care. The process of mitophagy involves the selective clearance of ageing and impaired mitochondria, which is required to preserve intracellular homeostasis and energy metabolism. Currently, it has been discovered that mitophagy abnormalities are intimately linked to the beginning and progression of AD. This article discusses the mechanism of mitophagy, abnormal mitophagy, and therapeutic effects in AD. The purpose is to offer fresh perspectives on the causes and remedies of AD.

Keywords: Alzheimer's disease (AD), mitochondrial damage, mitophagy, PINK1, parkin, homeostasis.

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