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Current Medicinal Chemistry

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Research Article

Expression of Circulating miR-21 and -29 and their Association with Myocardial Fibrosis in Hypertrophic Cardiomyopathy

Author(s): Andreas Angelopoulos, Evangelos Oikonomou, Alexios Antonopoulos, Panagiotis Theofilis, Konstantinos Zisimos*, Ourania Katsarou, Maria Gazouli, George Lazaros, Paraskevi Papanikolaou, Gerasimos Siasos, Dimitris Tousoulis, Konstantinos Tsioufis and Charalambos Vlachopoulos

Volume 31, Issue 25, 2024

Published on: 30 January, 2024

Page: [3987 - 3996] Pages: 10

DOI: 10.2174/0109298673286017240103073130

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Abstract

Background: Hypertrophic Cardiomyopathy (HCM) is characterized by myocardial hypertrophy, fibrosis, and sarcomeric disarray.

Objective: To evaluate the expression levels of circulating miR-21 and -29 in patients with HCM and their association with clinical characteristics and myocardial fibrosis.

Methods: In this case-control study, 27 subjects with HCM, 13 subjects with hypertensive cardiomyopathy, and 10 control subjects were enrolled. Evaluation of patients’ functional capacity was made by the six-minute walk test. Echocardiographic measurements of left ventricle systolic and diastolic function were conducted. Cardiac magnetic resonance late gadolinium enhancement (LGE) -through a semiquantitative evaluation- was used in the assessment of myocardial fibrosis extent in HCM patients. The expression of miR-21 and -29 in peripheral blood samples of all patients was measured via the method of quantitative reverse transcription polymerase chain reaction.

Results: Circulating levels of miR-21 were higher in both hypertensive and HCM (p<0.001) compared to controls, while expression of miR-29 did not differ between the three studied groups. In patients with HCM and LGE-detected myocardial fibrosis in more than 4 out of 17 myocardial segments, delta CT miR-21 values were lower than in patients with myocardial LGE in 3 or fewer myocardial segments (2.71 ± 1.06 deltaCT vs. 3.50 ± 0.55 deltaCT, p<0.04), indicating the higher expression of circulating miR-21 in patients with more extensive myocardial fibrosis.

Conclusion: MiR-21 was overexpressed in patients with HCM and hypertensive cardiomyopathy. Importantly, in patients with HCM, more extensive myocardial fibrosis was associated with higher levels of miR-21.

Keywords: Hypertrophic cardiomyopathy, miR-21, miR-29, myocardial fibrosis, heart failure, echocardiography.

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