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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Research Article

自身免疫性疾病和改善疾病的抗风湿药物(DMARDs)与阿尔茨海默病和/或痴呆风险的关联:一项使用医疗保险受益人数据的人群研究

卷 20, 期 10, 2023

发表于: 26 January, 2024

页: [725 - 737] 页: 13

弟呕挨: 10.2174/0115672050289966240110041616

价格: $65

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摘要

目的:阿尔茨海默病(AD)和/或痴呆是一种流行的神经认知障碍，主要影响65岁以上的个体。确定AD和/或痴呆的具体原因可能具有挑战性，新出现的证据表明其与自身免疫性炎症条件(如类风湿性关节炎(RA))的潜在关联。本研究旨在评估报告自身免疫性疾病的医疗保险受益人中AD和/或痴呆的患病率。此外，本研究旨在确定使用疾病改善抗风湿药物(DMARDs)与不使用DMARDs的自身免疫性疾病患者AD和/或痴呆的比较患病率。 方法:对2017年和2018年医疗保险现行受益人调查(MCBS)数据进行横断面二次数据分析。MCBS数据包括全国代表性的医疗保险人口样本，主要是65岁及以上的人口，并提供去识别的患者信息。来自该数据集的自我报告自身免疫性疾病的患者被纳入分析。对人口统计学变量、慢性病和药物使用进行描述性分析。比较了患有和不患有自身免疫性疾病的患者之间AD和/或痴呆的患病率。采用后向逐步选择回归来确定与阿尔茨海默病和/或痴呆患病率相关的危险因素。 结果:该研究包括18929名医疗保险受益人，其中4405人被确定患有一种自身免疫性疾病。AD和/或痴呆的患病率在自身免疫性疾病患者中明显更高。多因素回归分析显示，RA与AD和/或痴呆的高风险显著相关。其他人口统计学因素，包括高龄、非裔美国人或西班牙裔、低体重指数、慢性缺血性心脏病、心肌梗死史、中风史、抑郁症、精神健康障碍和创伤性脑损伤，也显示出与AD和/或痴呆的统计学显著关联。与不使用DMARDs的患者相比，使用DMARDs的患者患AD和/或痴呆的可能性降低。 结论:本研究提供了RA与AD和/或痴呆风险增加之间关联的证据。研究结果表明，使用DMARD可能对自身免疫性疾病患者的AD和/或痴呆的发展有保护作用。

关键词: 痴呆症，阿尔茨海默病，自身免疫性疾病，类风湿关节炎，改善疾病的抗风湿药物，医疗保险当前受益人调查。

« Previous
[1]
Huang, J. Dementia. In: Merck Manual Professional Version; Merck Sharp & Dohme Corp: Kenilworth, NJ, 2021.
[2]
Huang, J. Dementia.Merck Manual Consumer Version; Merck Sharp & Dohme Corp: Kenilworth, NJ, 2021.
[3]
Gale, S.A.; Acar, D.; Daffner, K.R. Dementia. Am. J. Med., 2018, 131(10), 1161-1169.
[http://dx.doi.org/10.1016/j.amjmed.2018.01.022] [PMID: 29425707]
[4]
Alzheimer’s Association. 2021 Alzheimer’s disease facts and figures. Alzheimers Dement., 2021, 17(3), 327-406.
[http://dx.doi.org/10.1002/alz.12328] [PMID: 33756057]
[5]
Nichols, E.; Szoeke, C.E.I.; Vollset, S.E.; Abbasi, N.; Abd-Allah, F.; Abdela, J.; Aichour, M.T.E.; Akinyemi, R.O.; Alahdab, F.; Asgedom, S.W.; Awasthi, A.; Barker-Collo, S.L.; Baune, B.T.; Béjot, Y.; Belachew, A.B.; Bennett, D.A.; Biadgo, B.; Bijani, A.; Bin Sayeed, M.S.; Brayne, C.; Carpenter, D.O.; Carvalho, F.; Catalá-López, F.; Cerin, E.; Choi, J-Y.J.; Dang, A.K.; Degefa, M.G.; Djalalinia, S.; Dubey, M.; Duken, E.E.; Edvardsson, D.; Endres, M.; Eskandarieh, S.; Faro, A.; Farzadfar, F.; Fereshtehnejad, S-M.; Fernandes, E.; Filip, I.; Fischer, F.; Gebre, A.K.; Geremew, D.; Ghasemi-Kasman, M.; Gnedovskaya, E.V.; Gupta, R.; Hachinski, V.; Hagos, T.B.; Hamidi, S.; Hankey, G.J.; Haro, J.M.; Hay, S.I.; Irvani, S.S.N.; Jha, R.P.; Jonas, J.B.; Kalani, R.; Karch, A.; Kasaeian, A.; Khader, Y.S.; Khalil, I.A.; Khan, E.A.; Khanna, T.; Khoja, T.A.M.; Khubchandani, J.; Kisa, A.; Kissimova-Skarbek, K.; Kivimäki, M.; Koyanagi, A.; Krohn, K.J.; Logroscino, G.; Lorkowski, S.; Majdan, M.; Malekzadeh, R.; März, W.; Massano, J.; Mengistu, G.; Meretoja, A.; Mohammadi, M.; Mohammadi-Khanaposhtani, M.; Mokdad, A.H.; Mondello, S.; Moradi, G.; Nagel, G.; Naghavi, M.; Naik, G.; Nguyen, L.H.; Nguyen, T.H.; Nirayo, Y.L.; Nixon, M.R.; Ofori-Asenso, R.; Ogbo, F.A.; Olagunju, A.T.; Owolabi, M.O.; Panda-Jonas, S.; Passos, V.M.A.; Pereira, D.M.; Pinilla-Monsalve, G.D.; Piradov, M.A.; Pond, C.D.; Poustchi, H.; Qorbani, M.; Radfar, A.; Reiner, R.C., Jr; Robinson, S.R.; Roshandel, G.; Rostami, A.; Russ, T.C.; Sachdev, P.S.; Safari, H.; Safiri, S.; Sahathevan, R.; Salimi, Y.; Satpathy, M.; Sawhney, M.; Saylan, M.; Sepanlou, S.G.; Shafieesabet, A.; Shaikh, M.A.; Sahraian, M.A.; Shigematsu, M.; Shiri, R.; Shiue, I.; Silva, J.P.; Smith, M.; Sobhani, S.; Stein, D.J.; Tabarés-Seisdedos, R.; Tovani-Palone, M.R.; Tran, B.X.; Tran, T.T.; Tsegay, A.T.; Ullah, I.; Venketasubramanian, N.; Vlassov, V.; Wang, Y-P.; Weiss, J.; Westerman, R.; Wijeratne, T.; Wyper, G.M.A.; Yano, Y.; Yimer, E.M.; Yonemoto, N.; Yousefifard, M.; Zaidi, Z.; Zare, Z.; Vos, T.; Feigin, V.L.; Murray, C.J.L. Global, regional, and national burden of Alzheimer’s disease and other dementias, 1990–2016: A systematic analysis for the Global burden of disease study 2016. Lancet Neurol., 2019, 18(1), 88-106.
[http://dx.doi.org/10.1016/S1474-4422(18)30403-4] [PMID: 30497964]
[6]
Rajan, KB; Weuve, J; Barnes, LL; McAninch, EA; Wilson, RS; Evans, DA Population estimate of people with clinical Alzheimer's disease and mild cognitive impairment in the United States (2020-2060). Alzheimers Dement, 2021, 17(12), 1966-1975.
[7]
Ahmad, F.B.; Anderson, R.N. The leading causes of death in the US for 2020. JAMA, 2021, 325(18), 1829-1830.
[http://dx.doi.org/10.1001/jama.2021.5469] [PMID: 33787821]
[8]
Burns, A.; Iliffe, S. Alzheimer’s disease. BMJ, 2009, 338(Feb 05), b158.
[http://dx.doi.org/10.1136/bmj.b158] [PMID: 19196745]
[9]
Atri, A. The Alzheimer’s disease clinical spectrum: Diagnosis and management. Med. Clin. North Am., 2019, 103(2), 263-293.
[http://dx.doi.org/10.1016/j.mcna.2018.10.009] [PMID: 30704681]
[10]
Jang, H.D.; Park, J.S.; Kim, D.W.; Han, K.; Shin, B.J.; Lee, J.C.; Choi, S.W.; Suh, S.W.; Yang, J.H.; Park, S.Y.; Cho, W.J.; Hong, J.Y. Relationship between dementia and ankylosing spondylitis: A nationwide, population-based, retrospective longitudinal cohort study. PLoS One, 2019, 14(1), e0210335.
[http://dx.doi.org/10.1371/journal.pone.0210335] [PMID: 30703142]
[11]
Lin, C.C.; Lin, H.C.; Chiu, H.W. Association between psoriasis and dementia: A population-based case-control study. Am. J. Clin. Dermatol., 2019, 20(3), 457-463.
[http://dx.doi.org/10.1007/s40257-018-00420-8] [PMID: 30649680]
[12]
Ungprasert, P.; Wijarnpreecha, K.; Thongprayoon, C. Rheumatoid arthritis and the risk of dementia: A systematic review and meta-analysis. Neurol. India, 2016, 64(1), 56-61.
[http://dx.doi.org/10.4103/0028-3886.173623] [PMID: 26754993]
[13]
Huang, KL; Yeh, CC; Wu, SI; Huang, KY; Yang, YH; Kuo, TY Risk of dementia among individuals with psoriasis: A nationwide population-based cohort study in Taiwan. J. Clin. Psychiatr., 2019, 80(3), 18m12462.
[14]
Zingel, R.; Bohlken, J.; Kostev, K. Association between inflammatory bowel disease and dementia: A retrospective cohort study. J. Alzheimers Dis., 2021, 80(4), 1471-1478.
[http://dx.doi.org/10.3233/JAD-210103] [PMID: 33720902]
[15]
Lin, Y.R.; Chou, L.C.; Chen, H.C.; Liou, T.H.; Huang, S.W.; Lin, H.W. Increased risk of dementia in patients with systemic lupus erythematosus: A nationwide population-based cohort study. Arthritis Care Res., 2016, 68(12), 1774-1779.
[http://dx.doi.org/10.1002/acr.22914] [PMID: 27111329]
[16]
Charoenngam, N.; Rittiphairoj, T.; Ponvilawan, B.; Ungprasert, P. Patients with psoriasis have a higher risk of dementia: A systematic review and meta-analysis. Indian J. Dermatol. Venereol. Leprol., 2021, 87(3), 364-370.
[http://dx.doi.org/10.25259/IJDVL_732_19] [PMID: 33666046]
[17]
Wang, Y.C.; Lin, M.S.; Huang, A.P.H.; Wu, C.C.; Kung, W.M. Association between systemic rheumatic diseases and dementia risk: A meta-analysis. Front. Immunol., 2022, 13, 1054246.
[http://dx.doi.org/10.3389/fimmu.2022.1054246] [PMID: 36439141]
[18]
Kodishala, C.; Hulshizer, C.A.; Kronzer, V.L.; Davis, J.M., III; Ramanan, V.K.; Vassilaki, M.; Mielke, M.M.; Crowson, C.S.; Myasoedova, E. Risk factors for dementia in patients with incident rheumatoid arthritis: A population-based cohort study. J. Rheumatol., 2023, 50(1), 48-55.
[http://dx.doi.org/10.3899/jrheum.220200] [PMID: 35840149]
[19]
Chen, K.T.; Chen, Y.C.; Fan, Y.H.; Lin, W.X.; Lin, W.C.; Wang, Y.H.; Lin, L.; Chiou, J.Y.; Wei, J.C.C. Rheumatic diseases are associated with a higher risk of dementia: A nation-wide, population-based, case-control study. Int. J. Rheum. Dis., 2018, 21(2), 373-380.
[http://dx.doi.org/10.1111/1756-185X.13246] [PMID: 29243407]
[20]
Gendelman, O.; Tiosano, S.; Shoenfeld, Y.; Comaneshter, D.; Amital, H.; Cohen, A.D.; Amital, D. High proportions of dementia among SLE patients: A big data analysis. Int. J. Geriatr. Psychiatry, 2018, 33(3), 531-536.
[http://dx.doi.org/10.1002/gps.4819] [PMID: 29114974]
[21]
Lin, T.M.; Chen, W.S.; Sheu, J.J.; Chen, Y.H.; Chen, J.H.; Chang, C.C. Autoimmune rheumatic diseases increase dementia risk in middle-aged patients: A nationwide cohort study. PLoS One, 2018, 13(1), e0186475.
[http://dx.doi.org/10.1371/journal.pone.0186475] [PMID: 29304089]
[22]
Rønnow Sand, J.; Troelsen, F.S.; Horváth-Puhó, E.; Henderson, V.W.; Sørensen, H.T.; Erichsen, R. Risk of dementia in patients with inflammatory bowel disease: A Danish population-based study. Aliment. Pharmacol. Ther., 2022, 56(5), 831-843.
[http://dx.doi.org/10.1111/apt.17119] [PMID: 35781292]
[23]
Wallin, K.; Solomon, A.; Kåreholt, I.; Tuomilehto, J.; Soininen, H.; Kivipelto, M. Midlife rheumatoid arthritis increases the risk of cognitive impairment two decades later: A population-based study. J. Alzheimers Dis., 2012, 31(3), 669-676.
[http://dx.doi.org/10.3233/JAD-2012-111736] [PMID: 22647255]
[24]
Wotton, C.J.; Goldacre, M.J. Associations between specific autoimmune diseases and subsequent dementia: Retrospective record-linkage cohort study, UK. J. Epidemiol. Community Health, 2017, 71(6), 576-583.
[http://dx.doi.org/10.1136/jech-2016-207809] [PMID: 28249989]
[25]
Yuan, S; Dan, L; Zhang, Y; Wu, J; Zhao, J; Kivipelto, M Digestive system diseases, genetic risk, and incident dementia: A prospective cohort study. Am. J. Prev. Med., 2023, S0749-3797(23)00433–6.
[http://dx.doi.org/10.1016/j.amepre.2023.10.017]
[26]
Zhang, B.; Wang, H.E.; Bai, Y.M.; Tsai, S.J.; Su, T.P.; Chen, T.J.; Wang, Y.P.; Chen, M.H. Inflammatory bowel disease is associated with higher dementia risk: A nationwide longitudinal study. Gut, 2021, 70(1), 85-91.
[http://dx.doi.org/10.1136/gutjnl-2020-320789] [PMID: 32576641]
[27]
Zhao, Z.; Rocha, N.P.; Salem, H.; Diniz, B.S.; Teixeira, A.L. The association between systemic lupus erythematosus and dementia A meta-analysis. Dement. Neuropsychol., 2018, 12(2), 143-151.
[http://dx.doi.org/10.1590/1980-57642018dn12-020006] [PMID: 29988333]
[28]
Zhou, M.; Xu, R.; Kaelber, D.C.; Gurney, M.E. Tumor Necrosis Factor (TNF) blocking agents are associated with lower risk for Alzheimer’s disease in patients with rheumatoid arthritis and psoriasis. PLoS One, 2020, 15(3), e0229819.
[http://dx.doi.org/10.1371/journal.pone.0229819] [PMID: 32203525]
[29]
Chou, R.C.; Kane, M.; Ghimire, S.; Gautam, S.; Gui, J. Treatment for rheumatoid arthritis and risk of alzheimer’s disease: A nested case-control analysis. CNS Drugs, 2016, 30(11), 1111-1120.
[http://dx.doi.org/10.1007/s40263-016-0374-z] [PMID: 27470609]
[30]
Ponvilawan, B.; Charoenngam, N.; Rittiphairoj, T.; Ungprasert, P. Ankylosing spondylitis is associated with an increased risk of dementia: A systematic review and meta-analysis. Int. J. Rheum. Dis., 2020, 23(11), 1452-1459.
[http://dx.doi.org/10.1111/1756-185X.13920] [PMID: 32715652]
[31]
Kim, M.; Park, H.E.; Lee, S.H.; Han, K.; Lee, J.H. Increased risk of Alzheimer’s disease in patients with psoriasis: A nationwide population-based cohort study. Sci. Rep., 2020, 10(1), 6454.
[http://dx.doi.org/10.1038/s41598-020-63550-2] [PMID: 32296117]
[32]
Simmons, C.R.; Zou, F.; Younkin, S.G.; Estus, S. Rheumatoid arthritis-associated polymorphisms are not protective against Alzheimer’s disease. Mol. Neurodegener., 2011, 6(1), 33.
[http://dx.doi.org/10.1186/1750-1326-6-33] [PMID: 21595938]
[33]
Aggarwal, M.; Alkhayyat, M.; Abou Saleh, M.; Sarmini, M.T.; Singh, A.; Garg, R.; Garg, P.; Mansoor, E.; Padival, R.; Cohen, B.L. Alzheimer disease occurs more frequently in patients with inflammatory bowel disease: Insight from a nationwide study. J. Clin. Gastroenterol., 2023, 57(5), 501-507.
[http://dx.doi.org/10.1097/MCG.0000000000001714] [PMID: 35470286]
[34]
Szandruk-Bender, M.; Wiatrak, B.; Szeląg, A. The risk of developing Alzheimer’s disease and Parkinson’s disease in patients with inflammatory bowel disease: A meta-analysis. J. Clin. Med., 2022, 11(13), 3704.
[http://dx.doi.org/10.3390/jcm11133704] [PMID: 35806985]
[35]
Watad, A.; McGonagle, D.; Anis, S.; Carmeli, R.; Cohen, A.D.; Tsur, A.M.; Ben-Shabat, N.; Luigi Bragazzi, N.; Lidar, M.; Amital, H. TNF inhibitors have a protective role in the risk of dementia in patients with ankylosing spondylitis: Results from a nationwide study. Pharmacol. Res., 2022, 182, 106325.
[http://dx.doi.org/10.1016/j.phrs.2022.106325] [PMID: 35752359]
[36]
Sangha, P.S.; Thakur, M.; Akhtar, Z.; Ramani, S.; Gyamfi, R.S. The link between rheumatoid arthritis and dementia: A review. Cureus, 2020, 12(4), e7855.
[http://dx.doi.org/10.7759/cureus.7855] [PMID: 32489719]
[37]
Newby, D.; Prieto-Alhambra, D.; Duarte-Salles, T.; Ansell, D.; Pedersen, L.; van der Lei, J.; Mosseveld, M.; Rijnbeek, P.; James, G.; Alexander, M.; Egger, P.; Podhorna, J.; Stewart, R.; Perera, G.; Avillach, P.; Grosdidier, S.; Lovestone, S.; Nevado-Holgado, A.J. Methotrexate and relative risk of dementia amongst patients with rheumatoid arthritis: A multi-national multi-database case-control study. Alzheimers Res. Ther., 2020, 12(1), 38.
[http://dx.doi.org/10.1186/s13195-020-00606-5] [PMID: 32252806]
[38]
Huang, L.C.; Chang, Y.H.; Yang, Y.H. Can disease-modifying anti-rheumatic drugs reduce the risk of developing dementia in patients with rheumatoid arthritis? Neurotherapeutics, 2019, 16(3), 703-709.
[http://dx.doi.org/10.1007/s13311-019-00715-6] [PMID: 30945124]
[39]
Judge, A.; Garriga, C.; Arden, N.K.; Lovestone, S.; Prieto-Alhambra, D.; Cooper, C.; Edwards, C.J. Protective effect of antirheumatic drugs on dementia in rheumatoid arthritis patients. Alzheimers Dement., 2017, 3(4), 612-621.
[http://dx.doi.org/10.1016/j.trci.2017.10.002] [PMID: 29201995]
[40]
Sattui, S.E.; Navarro-Millan, I.; Xie, F.; Rajan, M.; Yun, H.; Curtis, J.R. Incidence of dementia in patients with rheumatoid arthritis and association with disease modifying anti-rheumatic drugs – Analysis of a national claims database. Semin. Arthritis Rheum., 2022, 57, 152083.
[http://dx.doi.org/10.1016/j.semarthrit.2022.152083] [PMID: 36155968]
[41]
Zheng, C.; Fillmore, N.R.; Ramos-Cejudo, J.; Brophy, M.; Osorio, R.; Gurney, M.E.; Qiu, W.Q.; Au, R.; Perry, G.; Dubreuil, M.; Chen, S.G.; Qi, X.; Davis, P.B.; Do, N.; Xu, R. Potential long-term effect of tumor necrosis factor inhibitors on dementia risk: A propensity score matched retrospective cohort study in US veterans. Alzheimers Dement., 2022, 18(6), 1248-1259.
[http://dx.doi.org/10.1002/alz.12465] [PMID: 34569707]
[42]
Cooper, J.; Pastorello, Y.; Slevin, M. A meta-analysis investigating the relationship between inflammation in autoimmune disease, elevated CRP, and the risk of dementia. Front. Immunol., 2023, 14, 1087571.
[http://dx.doi.org/10.3389/fimmu.2023.1087571] [PMID: 36776896]
[43]
Yeung, C.H.C.; Au Yeung, S.L.; Schooling, C.M. Association of autoimmune diseases with Alzheimer’s disease: A mendelian randomization study. J. Psychiatr. Res., 2022, 155, 550-558.
[http://dx.doi.org/10.1016/j.jpsychires.2022.09.052] [PMID: 36198219]
[44]
Kridin, K.; Linder, D.; Shalom, G.; Piaserico, S.; Babaev, M.; Freud, T.; Comaneshter, D.; Cohen, A. Psoriasis and dementia: A cross-sectional study of 121,801 patients. Acta Derm. Venereol., 2020, 100(15), adv00250.
[http://dx.doi.org/10.2340/00015555-3595] [PMID: 32725254]
[45]
Cai, Q.; Xin, Z.; Zuo, L.; Li, F.; Liu, B. Alzheimer’s disease and rheumatoid arthritis: A Mendelian randomization study. Front. Neurosci., 2018, 12, 627.
[http://dx.doi.org/10.3389/fnins.2018.00627] [PMID: 30258348]
[46]
Min, C.; Bang, W.J.; Kim, M.; Oh, D.J.; Choi, H.G. Rheumatoid arthritis and neurodegenerative dementia: A nested case-control study and a follow-up study using a national sample cohort. Clin. Rheumatol., 2020, 39(1), 159-166.
[http://dx.doi.org/10.1007/s10067-019-04769-x] [PMID: 31523786]
[47]
Wu, C.Y.; Hu, H.Y.; Chou, Y.J.; Li, C.P.; Chang, Y.T. Psoriasis is not a risk factor for dementia: A 12-year nationwide population-based cohort study. Arch. Dermatol. Res., 2020, 312(9), 657-664.
[http://dx.doi.org/10.1007/s00403-020-02057-2] [PMID: 32152723]
[48]
Bae, S.C.; Lee, Y.H. Causal association between rheumatoid arthritis and a decreased risk of Alzheimer’s disease. Z. Rheumatol., 2019, 78(4), 359-364.
[http://dx.doi.org/10.1007/s00393-018-0504-8] [PMID: 29974225]
[49]
Kao, L.T.; Kang, J.H.; Lin, H.C.; Huang, C.C.; Lee, H.C.; Chung, S.D. Rheumatoid arthritis was negatively associated with Alzheimer’s disease: A population-based case-control study. PLoS One, 2016, 11(12), e0168106.
[http://dx.doi.org/10.1371/journal.pone.0168106] [PMID: 27997574]
[50]
Policicchio, S.; Ahmad, A.N.; Powell, J.F.; Proitsi, P. Rheumatoid arthritis and risk for Alzheimer’s disease: A systematic review and meta-analysis and a Mendelian Randomization study. Sci. Rep., 2017, 7(1), 12861.
[http://dx.doi.org/10.1038/s41598-017-13168-8] [PMID: 28993680]
[51]
Cheng, C-Y. Psoriasis is not associated with the risk of dementia: A population-based cohort study. J. Am. Acad. Dermatol., 2020.
[PMID: 32891780]
[52]
Chou, M.H.; Wang, J.Y.; Lin, C.L.; Chung, W.S. DMARD use is associated with a higher risk of dementia in patients with rheumatoid arthritis: A propensity score-matched case–control study. Toxicol. Appl. Pharmacol., 2017, 334, 217-222.
[http://dx.doi.org/10.1016/j.taap.2017.09.014] [PMID: 28927738]
[53]
Desai, R.J.; Varma, V.R.; Gerhard, T.; Segal, J.; Mahesri, M.; Chin, K.; Horton, D.B.; Kim, S.C.; Schneeweiss, S.; Thambisetty, M. Comparative risk of Alzheimer disease and related dementia among Medicare beneficiaries with rheumatoid arthritis treated with targeted disease-modifying antirheumatic agents. JAMA Netw. Open, 2022, 5(4), e226567.
[http://dx.doi.org/10.1001/jamanetworkopen.2022.6567] [PMID: 35394510]
[54]
Andrews, S.J.; Goate, A. Mendelian randomization indicates that TNF is not causally associated with Alzheimer’s disease. Neurobiol. Aging, 2019, 84, 241.e1-241.e3.
[http://dx.doi.org/10.1016/j.neurobiolaging.2019.09.003] [PMID: 31587925]
[55]
Booth, M.J.; Kobayashi, L.C.; Janevic, M.R.; Clauw, D.; Piette, J.D. No increased risk of Alzheimer’s disease among people with immune-mediated inflammatory diseases: Findings from a longitudinal cohort study of U.S. older adults. BMC Rheumatol., 2021, 5(1), 48.
[http://dx.doi.org/10.1186/s41927-021-00219-x] [PMID: 34763722]
[56]
Lu, K.; Wang, H.K.; Yeh, C.C.; Huang, C.Y.; Sung, P.S.; Wang, L.C.; Muo, C.H.; Sung, F.C.; Chen, H.J.; Li, Y.C.; Chang, L.C.; Tsai, K.J. Association between autoimmune rheumatic diseases and the risk of dementia. BioMed Res. Int., 2014, 2014, 1-7.
[http://dx.doi.org/10.1155/2014/861812] [PMID: 24877143]
[57]
Medicare Current Beneficiary Survey (MCBS) Available from: https://www.cms.gov/data-research/research/medicare-current-beneficiary-survey
[58]
Adler, G.S. A profile of the medicare current beneficiary survey. Health Care Financ. Rev., 1994, 15(4), 153-163.
[PMID: 10138483]
[59]
National Institutes of Health, Office of Human Subjects Research Protection. Types of research: human subjects research vs. not human subjects research. NIH investigator manual for human subjects research; U.S. Department of Health and Human Services, National Institutes of Health, 2022.
[60]
Medicare Current Beneficiary Survey Methodology Report; Centers for Medicare & Medicaid Services, 2017.
[61]
Medicare Current Beneficiary Survey Methodology Report; Centers for Medicare & Medicaid Services, 2018.
[62]
Vandenbroucke, J.P.; von Elm, E.; Altman, D.G.; Gøtzsche, P.C.; Mulrow, C.D.; Pocock, S.J.; Poole, C.; Schlesselman, J.J.; Egger, M. Strengthening the reporting of observational studies in epidemiology (STROBE): Explanation and elaboration. PLoS Med., 2007, 4(10), e297.
[http://dx.doi.org/10.1371/journal.pmed.0040297] [PMID: 17941715]
[63]
The strengthening the reporting of observational studies in epidemiology (STROBE) statement: Guidelines for reporting observational studies: STROBE Checklist: cohort, case-control, and cross-sectional studies (combined). 2023. Available from: https://www.strobe-statement.org/download/strobe-checklist-wide-cohort-case-control-and-cross-sectional-studies-combined-doc
[64]
Kronzer, V.L.; Crowson, C.S.; Davis, J.M., III; Vassilaki, M.; Mielke, M.M.; Myasoedova, E. Trends in incidence of dementia among patients with rheumatoid arthritis: A population-based cohort study. Semin. Arthritis Rheum., 2021, 51(4), 853-857.
[http://dx.doi.org/10.1016/j.semarthrit.2021.06.003] [PMID: 34174733]
[65]
Li, X.; Sundquist, J.; Zöller, B.; Sundquist, K. Dementia and Alzheimer’s disease risks in patients with autoimmune disorders. Geriatr. Gerontol. Int., 2018, 18(9), 1350-1355.
[http://dx.doi.org/10.1111/ggi.13488] [PMID: 30044040]
[66]
Li, P.; Zheng, Y.; Chen, X. Drugs for autoimmune inflammatory diseases: From small molecule compounds to anti-TNF biologics. Front. Pharmacol., 2017, 8, 460.
[http://dx.doi.org/10.3389/fphar.2017.00460] [PMID: 28785220]
[67]
Tarkowski, E.; Andreasen, N.; Tarkowski, A.; Blennow, K. Intrathecal inflammation precedes development of Alzheimer’s disease. J. Neurol. Neurosurg. Psychiatry, 2003, 74(9), 1200-1205.
[http://dx.doi.org/10.1136/jnnp.74.9.1200] [PMID: 12933918]
[68]
Vadasz, Z.; Haj, T.; Kessel, A.; Toubi, E. Age-related autoimmunity. BMC Med., 2013, 11(1), 94.
[http://dx.doi.org/10.1186/1741-7015-11-94] [PMID: 23556986]
[69]
Rajan, K.B.; Weuve, J.; Barnes, L.L.; Wilson, R.S.; Evans, D.A. Prevalence and incidence of clinically diagnosed Alzheimer’s disease dementia from 1994 to 2012 in a population study. Alzheimers Dement., 2019, 15(1), 1-7.
[http://dx.doi.org/10.1016/j.jalz.2018.07.216] [PMID: 30195482]
[70]
Gillis, C.; Montenigro, P.; Nejati, M.; Maserejian, N. Estimating prevalence of early Alzheimer’s disease in the United States, accounting for racial and ethnic diversity. Alzheimers Dement., 2023, 19(5), 1841-1848.
[http://dx.doi.org/10.1002/alz.12822] [PMID: 36322470]
[71]
Singh-Manoux, A.; Dugravot, A.; Shipley, M.; Brunner, E.J.; Elbaz, A.; Sabia, S.; Kivimaki, M. Obesity trajectories and risk of dementia: 28 years of follow-up in the Whitehall II Study. Alzheimers Dement., 2018, 14(2), 178-186.
[http://dx.doi.org/10.1016/j.jalz.2017.06.2637] [PMID: 28943197]
[72]
Pegueroles, J.; Jiménez, A.; Vilaplana, E.; Montal, V.; Carmona-Iragui, M.; Pané, A.; Alcolea, D.; Videla, L.; Casajoana, A.; Clarimón, J.; Ortega, E.; Vidal, J.; Blesa, R.; Lleó, A.; Fortea, J. Obesity and Alzheimer’s disease, does the obesity paradox really exist? A magnetic resonance imaging study. Oncotarget, 2018, 9(78), 34691-34698.
[http://dx.doi.org/10.18632/oncotarget.26162] [PMID: 30410669]
[73]
Li, J.; Liu, C.; Ang, T.F.A.; Au, R. BMI decline patterns and relation to dementia risk across four decades of follow-up in the Framingham Study. Alzheimers Dement., 2023, 19(6), 2520-2527.
[http://dx.doi.org/10.1002/alz.12839] [PMID: 36519667]
[74]
Fitzpatrick, A.L.; Kuller, L.H.; Lopez, O.L.; Diehr, P.; O’Meara, E.S.; Longstreth, W.T., Jr; Luchsinger, J.A. Midlife and late-life obesity and the risk of dementia: Cardiovascular health study. Arch. Neurol., 2009, 66(3), 336-342.
[http://dx.doi.org/10.1001/archneurol.2008.582] [PMID: 19273752]
[75]
Malone, D.C.; McLaughlin, T.P.; Wahl, P.M.; Leibman, C.; Arrighi, H.M.; Cziraky, M.J.; Mucha, L.M. Burden of Alzheimer’s disease and association with negative health outcomes. Am. J. Manag. Care, 2009, 15(8), 481-488.
[PMID: 19670951]
[76]
Widdifield, J.; Paterson, J.M.; Bernatsky, S.; Tu, K.; Thorne, J.C.; Ahluwalia, V.; Ivers, N.; Butt, D.; Jaakkimainen, R.L.; Tomlinson, G.; Bombardier, C. The rising burden of rheumatoid arthritis surpasses rheumatology supply in Ontario. Can. J. Public Health, 2013, 104(7), e450-e455.
[http://dx.doi.org/10.17269/cjph.104.4115] [PMID: 24495819]
[77]
Widdifield, J.; Bombardier, C.; Bernatsky, S.; Paterson, J.M.; Green, D.; Young, J.; Ivers, N.; Butt, D.A.; Jaakkimainen, R.L.; Thorne, J.C.; Tu, K. An administrative data validation study of the accuracy of algorithms for identifying rheumatoid arthritis: The influence of the reference standard on algorithm performance. BMC Musculoskelet. Disord., 2014, 15(1), 216.
[http://dx.doi.org/10.1186/1471-2474-15-216] [PMID: 24956925]

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