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Review Article

通过果蝇模型探索治疗帕金森病的有效天然产物

卷 25, 期 2, 2024

发表于: 10 January, 2024

页: [77 - 93] 页: 17

弟呕挨: 10.2174/0113894501281402231218071641

价格: $65

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摘要

帕金森病(PD)是一种严重的神经退行性疾病，部分原因是突变、环境毒素、氧化应激、异常蛋白质聚集和线粒体功能障碍。然而，帕金森病的确切发病机制及其治疗策略仍需进一步研究。幸运的是，由于其神经保护特性，天然产物已被证明有可能作为缓解PD症状的治疗剂。为了从草药天然产物中发现有潜力的PD治疗先导化合物并了解其作用模式，需要合适的动物模型。果蝇(Drosophila melanogaster)是研究复杂生物过程中遗传和细胞途径的重要模型。多种多样的果蝇PD模型被广泛应用于PD研究，特别是用于发现神经保护的天然产物。本文综述了利用果蝇帕金森病模型研究帕金森病天然产物的进展，为利用无脊椎动物模型开发新型抗帕金森病药物提供有价值的见解。

关键词: 帕金森病，黑胃果蝇，天然产物，中药，神经退行性疾病，草药，活性化合物。

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