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Review Article

脑再生中的转录因子:一个潜在的新治疗靶点

卷 25, 期 1, 2024

发表于: 14 December, 2023

页: [46 - 61] 页: 16

弟呕挨: 10.2174/0113894501279977231210170231

价格: $65

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摘要

转录因子在提供每个细胞群的身份方面起着至关重要的作用。为了维持细胞的特性，必须平衡激活因子和抑制因子的表达。细胞可塑性和重编程为未来的治疗应用提供了巨大的潜力，因为它们可以再生受损组织。特定的生态位因子可以改变基因表达，使目标细胞分化或转分化到所需的命运。目前正在进行的研究是关于再生神经元中转录因子的可能性，神经干细胞(NSCs)被认为是产生新神经元的首选细胞，因为它们具有表观基因组和转录组记忆。NEUROD1/ASCL1、BRN2、MYTL1等转录因子可诱导成纤维细胞等体细胞直接重编程为神经元。然而，转录因子在重编程和分化中的分子生物学作用仍有待进一步研究。

关键词: 转录、转分化、神经退行性、细胞可塑性、细胞治疗、再生、神经发生、细胞谱系、细胞命运、转基因、NEUROD1、ASCL1、BRN2、MYTL1。

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