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ISSN (Print): 1874-6098
ISSN (Online): 1874-6128

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Review Article

Repercussion of Primary Nucleation Pathway: Dementia and Cognitive Impairment

Author(s): Aditya Singh, Vaseem A. Ansari*, Tarique Mahmood, Farogh Ahsan and Shubhrat Maheshwari

Volume 17, Issue 3, 2024

Published on: 11 December, 2023

Page: [196 - 204] Pages: 9

DOI: 10.2174/0118746098243327231117113748

Price: $65

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Abstract

Neurodegenerative diseases, such as Alzheimer's, Parkinson's, and prion disease, are characterized by the conversion of normally soluble proteins or peptides into aggregated amyloidal fibrils. These diseases result in the permanent loss of specific types of neurons, making them incurable and devastating. Research on animal models of memory problems mentioned in this article contributes to our knowledge of brain health and functionality. Neurodegenerative disorders, which often lead to cognitive impairment and dementia, are becoming more prevalent as global life expectancy increases. These diseases cause severe neurological impairment and neuronal death, making them highly debilitating. Exploring and understanding these complex diseases offer significant insights into the fundamental processes essential for maintaining brain health. Exploring the intricate mechanisms underlying neurodegenerative diseases not only holds promise for potential treatments but also enhances our understanding of fundamental brain health and functionality. By unraveling the complexities of these disorders, researchers can pave the way for advancements in diagnosis, treatment, and ultimately, improving the lives of individuals affected by neurodegenerative diseases.

Keywords: Dementia, cognitive impairment, neurodegenerative, biomarkers, memory, fibrils, neurons, disease.

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