Advances in Nano Drugs for Cancer Chemotherapy

I.      Ali; Rahis-Uddin; K.      Salim; M.      A. Rather; W.      A. Wani; A.      Haque

doi:10.2174/156800911794328493

Abstract

In spite of some medications, millions of people are dying every year due to cancer. Additionally, the survival patients suffer from various serious side effects due to the use of available anti-neoplastic medicines. The development of nanoparticle based drugs seems to be effective providing low side effects and targeted action on cancer cells. The present article describes the state-of-the-art of nano drugs in cancer chemotherapy. The nano drugs are target selective and specific towards tumors only resulting into better treatment. The important molecules used for preparation nano drugs are cisplatin, carboplatin, bleomycin, 5-fluorouracil, doxorubicin, dactinomycin, 6-mercaptopurine, paclitaxel, topotecan, vinblastin and etoposide etc. The most commonly used materials for nanoparticle carriers are dendrimers, polymers, liposomes, micelles, inorganic, organic nanoparticles etc. A survey was carried out on the drugs available in the market and given in tabular form. However, the commonly used nano drugs till date are liposome dendrimer and some other materials based on nanoparticles. Attempts have been made to explain the mechanism of action of nano drugs. The future perspectives have also been highlighted in the conclusion part.

Keywords: Cancer, nano drugs, chemotherapy, mechanism of action, cisplatin, carboplatin, bleomycin, 5-fluorouracil, doxorubicin, dactinomycin, 6-mercaptopurine, paclitaxel, topotecan, vinblastin, etoposide, liposomes, micelles, Nanoparticles, Nanotechnology, oncology, cytotoxic anti-cancer, solid lipid nanoparticles, polyethylene glycol, albumin, polyalkylcya-noacrylate, polylactic acid, polyglycolic acid, relative extraction efficiency, sulfdiazine, gadolin-ium diethylenetriaminepentaacetic acid, camptothecin, amikacin, vancomycin, cholesterol, soya L-lecithin, leukemia cells, sodium dodecyl sulfate, carbon nano-tubes, Indometacin, 5-fluorouracil, glycol chi-tosans (HGCs), dynamic light scattering, nano-electromechanical systems, methotrexate, antigens, Docetaxel, Deoxyuridine triphosphate, 5- Fluorouracil, Fluorodeoxyuridine, Inhibitory concentration, Protein, Sulfadiazine