Silica Nanoparticles as Promising Drug/Gene Delivery Carriers and Fluorescent Nano-Probes: Recent Advances

Y.      Liu; C.      Lou; H.      Yang; M.      Shi; H.      Miyoshi

doi:10.2174/156800911794328411

Abstract

The application of nanotechnology to biomedical research is expected to have a major impact leading to the development of new types of diagnostic and therapeutic tools. One focus in nanobiotechnology is to develop safe and efficient drug/gene delivery vehicles. Research into the rational delivery and targeting of pharmaceutical, therapeutic and diagnostic agents is at the forefront of projects in nanomedicine. Silica, as a major and natural component of sand and glass, is a versatile material due to the variety of available chemical and physical modifications that are available, and recently have been widely applied in nanobiotechnology as drug/gene carriers or fluorescent nano-probes. The goal of this brief review is to illustrate selected examples of various functionalized silica nanoparticles as drug/gene delivery systems that have been applied to the arenas of human disease therapy or detection (molecular and cellular imaging).

Keywords: Silica, nanoparticles, drug/gene delivery, nano-probes, targeting, nanotechnology, nanobiotechnology, fluorescein isothiocyanate, sodium cyanide, tetraethoxysilane, thiol-organosilica, electrostatic interaction, plasmid DNA, stereotaxic injections, bromodeoxyuridine, photodynamic drugs, sol-gel, mesoporous channels, proliferation, apoptosis, cytoskeleton, liposomes, perfluorocarbon, luminescent, fluorescent dye, immunosorbent assay, immu-nocytochemistry, immunohistochemistry, DNA microarray, superparamagnetic iron ox-ide, mesenchymal stem cells, polyethylene glycol, glutaraldehyde, Folic acid, adenocarcinoma, pituitary adenoma, antisense oligonucleotides, 2-devinyl-2-(1-hexyloxyethyl) pyropheo-phorbide, mesoporous silica nanoparticles, superparamagnetic iron oxide