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Cardiovascular & Hematological Agents in Medicinal Chemistry

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ISSN (Print): 1871-5257
ISSN (Online): 1875-6182

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Review Article

Understanding the Relationship between the Ketogenic Diet and the Heart: A Novel Therapeutic Potential for Cardiovascular Health

Author(s): Priyanshi Shah*, Aanchal Sawhney, FNU Anamika, Sai Gautham Kanagala, Kinna Parikh, Vaidehi Mendpara, Nikita Garg and Rohit Jain

Volume 22, Issue 4, 2024

Published on: 21 November, 2023

Page: [407 - 412] Pages: 6

DOI: 10.2174/0118715257267341231031120105

Price: $65

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Abstract

Obesity and cardiovascular diseases are major health problems worldwide, and weight loss is used as a treatment strategy to enhance various aspects. While there are many weight loss methods, one of the most effective is through a dietary approach. The ketogenic diet (KD), which is characterized by low carbohydrates and high levels of fat and/or protein, is used in obese patients as it is a promising treatment option for weight loss as well as for controlling the risk factors for cardiovascular diseases, as seen in its effects on cardio-metabolic outcomes, particularly in obesity, heart failure, and hypertension. In this review, we summarize the clinical evidence of the efficacy and safety of the KD in controlling risk factors for cardiovascular diseases and discuss the possible mechanisms of action based on recent evidence in understanding the influence of the KD at the cellular and molecular levels.

Keywords: Ketogenic diet, cardiovascular disease, low-density lipoprotein, beta-hydroxybutyrate, obesity, carbohydrates.

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