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Research Article

硒、锌及其联合补充对肥胖大鼠心脏代谢生物标志物的影响——比较它们在能量限制和高脂饮食方法中的作用

卷 24, 期 10, 2024

发表于: 22 January, 2024

页: [1307 - 1315] 页: 9

弟呕挨: 10.2174/0115665240268180231113045836

价格: $65

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摘要

介绍：体内的脂肪分布决定了患心脏病和糖尿病等心脏代谢问题的风险。一些膳食补充剂，如硒和锌，具有溶脂和抗血管生成功能，这可能是降低心脏代谢并发症风险的有效策略。本研究在热量限制(CR)和高脂饮食(HFD)两种营养模型中，评价了锌(Zn)、硒(Se)及其联合补充对雄性Wistar大鼠心脏代谢危险因素的影响。 方法与材料：体内的脂肪分布决定了患心脏病和糖尿病等心脏代谢问题的风险。一些膳食补充剂，如硒和锌，具有溶脂和抗血管生成功能，这可能是降低心脏代谢并发症风险的有效策略。本研究在热量限制(CR)和高脂饮食(HFD)两种营养模型中，评价了锌(Zn)、硒(Se)及其联合补充对雄性Wistar大鼠心脏代谢危险因素的影响。 结果：结果显示，饲粮添加量显著改善了猪的脂质状况(P <0.001)。葡萄糖稳态指数在研究组的比较也显示出显著差异。HFD组血清葡萄糖水平高于干预组(P <0.001)。此外，接受两种补充剂组合的组的血脂和血糖指数的改善率比单独接受锌和硒的组表现出更好的趋势。然而，只有葡萄糖稳态指标的数值才有统计学意义(P <0.001)。 结论：尽管肥胖是一个多因素的疾病，控制其他危险因素，锌和硒及其联合补充可以为治疗肥胖引起的葡萄糖和脂质稳态紊乱提供有希望的解决方案。

关键词: 葡萄糖稳态，血脂，肥胖，抗氧化剂，心脏代谢生物标志物，高脂肪饮食。

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