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ISSN (Online): 2666-7975

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Review Article

Amidst Cytokine Storm in Metabolic Diseases: Can 2-deoxy-D-glucose (2-DG) Cure COVID-19?

Author(s): Shweta Shrivastava, Ayush Kumar, Manish Kumar Jeengar, Elsy Xavier and Prashant Tiwari*

Volume 5, Issue 2, 2024

Published on: 27 October, 2023

Article ID: e271023222860 Pages: 11

DOI: 10.2174/0126667975246836231019052126

Price: $65

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Abstract

The SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2)-related pandemic disease COVID-19, which began in China in 2019, became the leading cause of fatalities globally. The transmission rate of the virus is directly proportional to the so-called ‘dance dynamic’ energy of the spike protein as this phenomenon favours the ligand-receptor binding. The clinical spectrum of the COVID-19 disease, which includes (inflammation, cytokine storm, and multi-organ dysfunction), puts Corona Warriors active in various aspects of the disease, such as the efficient management of critically ill COVID-19 patients, in danger of losing their lives. Due to its effects on an ancient oxygen- independent glycolytic pathway, anti-inflammatory properties, and competitive interaction with viral proteins, 2-deoxy-D-glucose (2-DG), which is being developed in India at the Defence Research and Development Organization (DRDO), has emerged as a ground-breaking agent for COVID-19 treatment. After a virus gains entry into host cells, it is found that metabolic reprogramming takes place to meet the nutritional and energy requirements for virus reproduction. The recent approval of 2-DG for adjunctive emergency usage by the Drug Controller General of India (DCGI) may mark a turning point in the management of mild to moderate COVID-19 infection.

Keywords: SARS-CoV-2, COVID-19, 2-deoxy-D-glucose, metabolic disease, spike protein dynamics, aerobic glycolysis.

Graphical Abstract

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