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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Research Article

轻度认知障碍患者动脉自旋标记测量脑血流及其连接模式的改变

卷 20, 期 8, 2023

发表于: 25 October, 2023

页: [567 - 576] 页: 10

弟呕挨: 10.2174/0115672050241163231017073139

价格: $65

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摘要

目的：脑血流(CBF)是衡量脑功能的重要指标。研究表明，在轻度认知障碍(MCI)中，脑脑血流的区域变化不一致。动脉自旋标记法(ASL)广泛应用于轻度认知损伤患者脑血流的研究。然而，这些患者脑血流连通性的改变仍然知之甚少。 方法：在本研究中，采用3D伪连续动脉自旋标记(3D- pcasl)技术研究了32名MCI患者和32名健康对照者的区域CBF和CBF连通性的变化。规范化CBF用于减少受试者间差异。评估两组CBF比较以及CBF改变与认知评分之间的相关性。脑区脑血流连通性也在组间进行了比较。 结果：我们发现，与对照组相比，MCI患者左侧顶叶上回的CBF明显减少，而左侧中央前回、右侧颞上回、右侧壳核和左侧辅助运动区CBF增加。在轻度认知障碍患者中，CBF和神经心理学量表之间存在显著相关性。重要的是，MCI患者表现出左侧辅助运动区和左侧顶叶上回之间的CBF断开。 结论：本研究发现，与对照组相比，MCI患者不仅存在区域CBF的变化，而且CBF连接模式也发生了变化。这些观察结果可能为阿尔茨海默病和轻度认知损伤患者病理生理的神经机制提供新的解释。

关键词: 轻度认知障碍，阿尔茨海默病，动脉自旋标记，脑血流，脑血流连通性，脑功能。

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