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Review Article

SGK-1信号通路是缺血性损伤细胞存活的关键因素

卷 24, 期 14, 2023

发表于: 22 October, 2023

页: [1117 - 1126] 页: 10

弟呕挨: 10.2174/0113894501239948231013072901

价格: $65

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摘要

血清和糖皮质激素调节激酶(SGK)是属于AGC的丝氨酸/苏氨酸激酶。SGK-1对应激作出反应，控制一系列离子通道、细胞生长、转录因子、膜转运蛋白、细胞酶、细胞存活、增殖和死亡。其表达受高渗或等渗氧化应激、细胞收缩、辐射、高血糖、神经元损伤、DNA损伤、机械应力、热休克、兴奋、脱水和缺血等多种因素的高度控制。缺血一段时间后血流恢复后出现的结构和功能恶化被称为缺血/再灌注损伤(ischemia/ reperfusion injury, I/R)。本文综述了SGK-1的结构、表达、功能和降解，重点介绍了SGK-1在肾、心肌、脑、肠和肺等不同器官的各种缺血性损伤。此外，本综述强调了激活SGK-1通路并减缓I/R损伤进展的各种治疗药物。

关键词: SGK-1，炎症，氧化应激，缺血再灌注，细胞凋亡，细胞存活。

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