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Systematic Review Article

水飞蓟素/水飞蓟宾素在癌症中的放射增敏潜力:系统综述

卷 31, 期 42, 2024

发表于: 26 October, 2023

页: [6992 - 7014] 页: 23

弟呕挨: 10.2174/0109298673248404231006052436

价格: $65

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摘要

介绍：虽然放射治疗是主要的癌症治疗方式之一，但在治疗期间使健康器官/组织暴露于电离辐射和肿瘤对电离辐射的抵抗力是放射治疗的主要挑战，可能导致不同的不良反应。结果表明，放射治疗与天然生物活性化合物(如水飞蓟素/水飞蓟宾)联合治疗可减轻电离辐射引起的不良反应，并可诱导这些治疗方式之间的协同作用。本文对水飞蓟素/水飞蓟宾在肿瘤放射暴露/放疗中的潜在放射增敏作用进行了研究。 方法：根据PRISMA指南，系统检索截至2022年10月Google Scholar、PubMed、Web of Science、Scopus等不同电子数据库的相关研究。我们按照预先设定的纳入和排除标准筛选了843篇文章。本系统综述最终纳入了7项研究。 结果：与对照组相比，电离辐射处理的癌细胞的细胞存活/增殖明显减少，水飞蓟素/水飞蓟宾的使用协同增加了电离辐射诱导的细胞毒性。此外，与未治疗组相比，电离辐射治疗小鼠的肿瘤体积、重量和生长都有所减少，这些减少主要发生在放疗加水飞蓟素/水飞蓟宾治疗的小鼠中。此外，辐照导致肿瘤细胞/组织的一系列生化和组织病理学变化，并且电离辐射诱导的改变在水飞蓟素/水飞蓟宾给药后(在大多数情况下)是协同的。 结论：在大多数情况下，水飞蓟素/水飞蓟宾可通过增加自由基形成、诱导DNA损伤、增加细胞凋亡、抑制血管生成和转移等方式使癌细胞对电离辐射敏感。然而，建议水飞蓟素/水飞蓟宾在癌症患者放射治疗中的应用还需要进一步的临床研究。

关键词: 癌症，放疗，放射致敏，水飞蓟素，水飞蓟宾，系统综述。

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