Abstract
Background: The "diabetic lung" has been identified as a possible target organ in diabetes, with abnormalities in ventilation control, bronchomotor tone, lung volume, pulmonary diffusing capacity, and neuroadrenergic bronchial innervation.
Objective: This review summarizes studies related to diabetic pneumopathy, pathophysiology and a number of pulmonary disorders including type 1 and type 2 diabetes.
Methods: Electronic searches were conducted on databases such as Pub Med, Wiley Online Library (WOL), Scopus, Elsevier, ScienceDirect, and Google Scholar using standard keywords “diabetes,” “diabetes Pneumopathy,” “Pathophysiology,” “Lung diseases,” “lung infection” for review articles published between 1978 to 2023 very few previous review articles based their focus on diabetic pneumopathy and its pathophysiology.
Results: Globally, the incidence of diabetes mellitus has been rising. It is a chronic, progressive metabolic disease. The "diabetic lung" may serve as a model of accelerated ageing since diabetics' rate of respiratory function deterioration is two to three-times higher than that of normal, non-smoking people.
Conclusion: Diabetes-induced pulmonary dysfunction has not gained the attention it deserves due to a lack of proven causality and changes in cellular properties. The mechanism underlying a particular lung illness can still only be partially activated by diabetes but there is evidence that hyperglycemia is linked to pulmonary fibrosis in diabetic people.
Keywords: Diabetes, diabetes pneumopathy, pathophysiology, lung diseases, lung infection, pulmonary fibrosis.
[http://dx.doi.org/10.1002/advs.202100275] [PMID: 34319011]
[http://dx.doi.org/10.17267/2317-3386bjmhh.v4i1.791]
[http://dx.doi.org/10.1002/cphy.c150028] [PMID: 27065169]
[http://dx.doi.org/10.1016/j.puhe.2007.07.004] [PMID: 18028967]
[http://dx.doi.org/10.1038/s41572-019-0069-0] [PMID: 30872586]
[http://dx.doi.org/10.1007/s00421-010-1663-8] [PMID: 20936482]
[http://dx.doi.org/10.1183/13993003.00962-2016] [PMID: 28179436]
[http://dx.doi.org/10.1016/j.actbio.2012.04.044] [PMID: 22579983]
[http://dx.doi.org/10.1111/iep.12027] [PMID: 23718692]
[http://dx.doi.org/10.1002/cphy.c140049] [PMID: 27065170]
[http://dx.doi.org/10.1900/RDS.2019.15.1] [PMID: 30489598]
[http://dx.doi.org/10.1086/431587] [PMID: 16007521]
[http://dx.doi.org/10.1111/j.1464-5491.2010.03073.x] [PMID: 20722670]
[http://dx.doi.org/10.1038/s41590-020-0778-2] [PMID: 32839612]
[http://dx.doi.org/10.1002/dmrr.688] [PMID: 17013948]
[http://dx.doi.org/10.1089/ars.2021.0127] [PMID: 34913726]
[http://dx.doi.org/10.1210/er.2017-00173] [PMID: 28938479]
[http://dx.doi.org/10.1016/j.rmed.2008.04.013] [PMID: 18617381]
[http://dx.doi.org/10.1016/j.yjmcc.2022.10.007] [PMID: 36372279]
[http://dx.doi.org/10.1016/j.ejphar.2005.12.082] [PMID: 16487964]
[http://dx.doi.org/10.3389/fcell.2019.00259] [PMID: 31737627]
[http://dx.doi.org/10.1007/s00391-007-0484-9] [PMID: 17943238]
[http://dx.doi.org/10.3390/antiox12010147] [PMID: 36671009]
[http://dx.doi.org/10.1016/j.pharmthera.2019.02.013] [PMID: 30822464]
[http://dx.doi.org/10.1007/s00125-020-05164-x] [PMID: 32405783]
[http://dx.doi.org/10.1097/01.mcp.0000219270.73180.8b] [PMID: 16582676]
[http://dx.doi.org/10.1055/a-0653-7135] [PMID: 30142673]
[http://dx.doi.org/10.1093/ndt/16.3.459] [PMID: 11239016]
[http://dx.doi.org/10.1007/978-3-319-23672-8]
[http://dx.doi.org/10.3389/fendo.2021.765201] [PMID: 34899603]
[http://dx.doi.org/10.1186/s40842-017-0044-1] [PMID: 28702260]
[http://dx.doi.org/10.7759/cureus.33274] [PMID: 36741595]
[http://dx.doi.org/10.1016/j.phrs.2018.10.008] [PMID: 30312663]
[http://dx.doi.org/10.1164/rccm.200705-664OC] [PMID: 17761616]
[http://dx.doi.org/10.1016/j.rmed.2009.02.001] [PMID: 19251407]
[http://dx.doi.org/10.1002/eat.20875] [PMID: 22072403]
[http://dx.doi.org/10.1016/j.vaccine.2022.01.042] [PMID: 35140014]
[http://dx.doi.org/10.1007/s11095-006-9216-x] [PMID: 17333393]
[http://dx.doi.org/10.1038/s41419-019-1820-x] [PMID: 31391462]
[http://dx.doi.org/10.1080/17476348.2019.1556639] [PMID: 30517828]
[http://dx.doi.org/10.3390/jpm12091429] [PMID: 36143214]
[http://dx.doi.org/10.1183/09059180.00004914] [PMID: 25176967]
[http://dx.doi.org/10.1164/rccm.201701-0218PP] [PMID: 28128970]
[http://dx.doi.org/10.1080/17476348.2016.1176915] [PMID: 27070482]
[http://dx.doi.org/10.1007/s40273-018-0631-8] [PMID: 29492843]
[http://dx.doi.org/10.1146/annurev-pathol-012513-104706] [PMID: 24050627]
[http://dx.doi.org/10.1900/RDS.2012.9.23] [PMID: 22972442]
[http://dx.doi.org/10.1016/j.matbio.2016.01.012] [PMID: 26807760]
[http://dx.doi.org/10.1164/rccm.201210-1804CI] [PMID: 23590262]
[http://dx.doi.org/10.3390/ijms17111853] [PMID: 27834824]
[http://dx.doi.org/10.1016/j.ejcdt.2015.06.006]
[http://dx.doi.org/10.1186/s12931-021-01711-1] [PMID: 33865386]
[http://dx.doi.org/10.1016/j.dsx.2021.102360] [PMID: 34920193]
[http://dx.doi.org/10.1016/j.rmed.2004.11.012] [PMID: 15939250]
[http://dx.doi.org/10.4187/respcare.04398] [PMID: 26534999]
[http://dx.doi.org/10.1089/dia.2007.0227] [PMID: 17563307]
[http://dx.doi.org/10.1513/pats.201203-023AW] [PMID: 22802283]
[http://dx.doi.org/10.1016/j.phrs.2016.09.040] [PMID: 27697647]
[http://dx.doi.org/10.7759/cureus.26622] [PMID: 35949805]
[http://dx.doi.org/10.1164/ajrccm.156.1.9607090] [PMID: 9230730]
[http://dx.doi.org/10.3389/froh.2021.697428]
[http://dx.doi.org/10.3390/ijms21239005] [PMID: 33260799]
[http://dx.doi.org/10.14336/AD.2016.0627] [PMID: 28203478]
[http://dx.doi.org/10.1016/j.cgh.2014.06.034] [PMID: 25041866]
[http://dx.doi.org/10.1016/0002-9343(72)90078-2] [PMID: 5030170]
[http://dx.doi.org/10.1097/00000441-200109000-00003] [PMID: 11570776]
[http://dx.doi.org/10.1016/j.injms.2016.09.007]
[http://dx.doi.org/10.1186/s12872-021-01944-4] [PMID: 33731006]
[http://dx.doi.org/10.1038/s41582-020-0402-y] [PMID: 32843733]
[http://dx.doi.org/10.1016/j.envint.2017.12.037] [PMID: 29306794]
[http://dx.doi.org/10.1177/1479972307086313] [PMID: 18539724]
[http://dx.doi.org/10.1111/j.1600-0838.2006.00520.x] [PMID: 16451303]
[http://dx.doi.org/10.3390/ijerph18136970] [PMID: 34209922]
[http://dx.doi.org/10.1042/cs0960499]
[http://dx.doi.org/10.1007/978-3-031-13388-6_8]
[http://dx.doi.org/10.1007/s00246-020-02513-w] [PMID: 33394120]
[http://dx.doi.org/10.1152/physrev.00039.2018] [PMID: 31600121]
[http://dx.doi.org/10.46310/tjim.768962]
[http://dx.doi.org/10.1186/1475-2840-11-132] [PMID: 23101436]
[http://dx.doi.org/10.1183/09031936.06.00024505] [PMID: 16387952]
[http://dx.doi.org/10.1513/pats.200601-003TK] [PMID: 16738202]
[http://dx.doi.org/10.1002/adma.202210579] [PMID: 37119468]
[http://dx.doi.org/10.1146/annurev-physiol-021119-034610] [PMID: 31730381]
[http://dx.doi.org/10.1152/physrev.00023.2002] [PMID: 12663861]
[http://dx.doi.org/10.1152/ajpheart.00328.2013] [PMID: 24163075]
[http://dx.doi.org/10.1007/s00011-020-01372-8] [PMID: 32529477]
[http://dx.doi.org/10.1021/acs.jafc.6b03001] [PMID: 27538767]
[http://dx.doi.org/10.1161/HYPERTENSIONAHA.122.19586] [PMID: 35703100]
[http://dx.doi.org/10.1038/nature11130] [PMID: 22763554]
[http://dx.doi.org/10.1164/rccm.200304-505SO] [PMID: 14555458]
[http://dx.doi.org/10.1101/2021.04.29.21256294]
[http://dx.doi.org/10.1080/14656566.2021.1988074] [PMID: 34753370]
[http://dx.doi.org/10.1111/scd.12027] [PMID: 23795637]
[http://dx.doi.org/10.3390/metabo11020069] [PMID: 33530418]
[http://dx.doi.org/10.1111/j.1472-8206.2006.00425.x] [PMID: 16968414]
[http://dx.doi.org/10.1016/j.pulmoe.2021.03.003] [PMID: 33832850]
[http://dx.doi.org/10.1016/j.biopha.2018.02.105] [PMID: 29505922]
[http://dx.doi.org/10.1089/ars.2005.7.1568] [PMID: 16356120]
[http://dx.doi.org/10.1016/j.redox.2016.11.003] [PMID: 27888691]
[http://dx.doi.org/10.1016/j.bbadis.2012.11.021] [PMID: 23219955]
[http://dx.doi.org/10.1161/CIRCULATIONAHA.116.022362] [PMID: 32091921]
[http://dx.doi.org/10.3390/medicina57060536] [PMID: 34071880]
[http://dx.doi.org/10.1016/j.jconrel.2013.05.028] [PMID: 23735571]
[http://dx.doi.org/10.1007/s13402-019-00442-2] [PMID: 30980365]
[http://dx.doi.org/10.1074/jbc.M608565200] [PMID: 17327226]
[http://dx.doi.org/10.1089/ars.2005.7.1476] [PMID: 16356110]
[http://dx.doi.org/10.1186/s12943-022-01616-7] [PMID: 35836256]
[http://dx.doi.org/10.2337/db12-0190] [PMID: 23172950]
[http://dx.doi.org/10.1007/978-3-319-19701-2_4]
[http://dx.doi.org/10.1007/978-3-030-06200-2_8]
[http://dx.doi.org/10.1210/endrev/bnab007] [PMID: 33710268]
[http://dx.doi.org/10.1186/s12931-020-01334-y] [PMID: 32272932]
[http://dx.doi.org/10.1007/s00192-008-0737-1] [PMID: 18854909]
[http://dx.doi.org/10.1016/0034-5687(78)90104-4] [PMID: 644146]
[http://dx.doi.org/10.3389/fpubh.2020.00196] [PMID: 32582606]
[http://dx.doi.org/10.1016/j.ejphar.2010.03.048] [PMID: 20371238]
[http://dx.doi.org/10.1016/j.phrs.2016.02.026] [PMID: 26956523]
[http://dx.doi.org/10.1097/01.med.0000216972.61160.8c]
[http://dx.doi.org/10.1016/j.lfs.2018.03.032] [PMID: 29567077]
[http://dx.doi.org/10.1681/ASN.2006050525] [PMID: 16914537]
[http://dx.doi.org/10.1016/j.radonc.2010.09.002] [PMID: 20888056]
[http://dx.doi.org/10.1165/rcmb.2015-0311OC] [PMID: 27447052]
[http://dx.doi.org/10.1002/cbf.3229] [PMID: 27859423]
[http://dx.doi.org/10.1016/j.phrs.2018.07.006] [PMID: 29990624]
[http://dx.doi.org/10.1002/dmrr.1175] [PMID: 21309056]
[http://dx.doi.org/10.4252/wjsc.v11.i10.787] [PMID: 31692986]
[http://dx.doi.org/10.1002/dmrr.3377] [PMID: 32588943]
[http://dx.doi.org/10.1016/S0002-9343(97)00251-9] [PMID: 9428834]
[http://dx.doi.org/10.1016/S0168-8227(85)80034-6] [PMID: 3836101]
[PMID: 4054261]
[http://dx.doi.org/10.1136/thx.44.4.251] [PMID: 2763226]
[http://dx.doi.org/10.1152/jappl.2001.90.3.889]
[http://dx.doi.org/10.1111/j.1464-5491.2008.02571.x] [PMID: 19046231]
[http://dx.doi.org/10.1155/2006/834786] [PMID: 16779465]
[http://dx.doi.org/10.1016/j.tem.2020.01.007] [PMID: 32033865]
[http://dx.doi.org/10.1152/ajplung.90482.2008] [PMID: 18790989]
[http://dx.doi.org/10.1378/chest.124.3.1090] [PMID: 12970042]
[http://dx.doi.org/10.1007/s00408-022-00523-4] [PMID: 35267072]
[http://dx.doi.org/10.1038/s41598-021-93191-y] [PMID: 34226597]
[http://dx.doi.org/10.1136/thorax.55.suppl_1.S41] [PMID: 10943638]
[http://dx.doi.org/10.1016/j.diabet.2008.08.001] [PMID: 18829364]
[http://dx.doi.org/10.1001/jama.2021.20939] [PMID: 34905031]
[http://dx.doi.org/10.1159/000111820] [PMID: 18042978]
[http://dx.doi.org/10.2337/dc19-1125] [PMID: 31636081]
[http://dx.doi.org/10.1183/1025448x.00043015]
[http://dx.doi.org/10.2147/JIR.S163248] [PMID: 29844694]
[http://dx.doi.org/10.2174/1573399811666150817124601] [PMID: 26279493]
[http://dx.doi.org/10.1186/s13098-017-0294-1] [PMID: 29201153]
[http://dx.doi.org/10.1155/2017/6710278] [PMID: 28589151]
[http://dx.doi.org/10.1039/D0CS00705F] [PMID: 32760967]
[http://dx.doi.org/10.1210/clinem/dgac558] [PMID: 36181458]
[http://dx.doi.org/10.1038/ki.2008.516] [PMID: 19034325]
[http://dx.doi.org/10.1371/journal.pone.0233147] [PMID: 32392262]
[PMID: 23055717]
[http://dx.doi.org/10.1007/s00228-009-0682-z] [PMID: 19557399]
[http://dx.doi.org/10.1111/bcp.12334] [PMID: 25099256]
[http://dx.doi.org/10.1016/j.molmet.2020.101044] [PMID: 32585364]
[http://dx.doi.org/10.1183/23120541.00114-2016] [PMID: 28656133]
[http://dx.doi.org/10.4103/ijem.IJEM_159_17] [PMID: 30766827]
[http://dx.doi.org/10.1016/j.jaut.2014.03.005] [PMID: 24767831]
[http://dx.doi.org/10.1055/s-0035-1547319]
[http://dx.doi.org/10.2337/diacare.26.3.764] [PMID: 12610035]
[http://dx.doi.org/10.3389/fendo.2017.00006] [PMID: 28167928]
[http://dx.doi.org/10.1038/nrdp.2015.2] [PMID: 27189141]
[http://dx.doi.org/10.1016/j.jclinepi.2010.07.015] [PMID: 21208779]
[http://dx.doi.org/10.1038/s41572-019-0127-7] [PMID: 31727986]
[http://dx.doi.org/10.1016/j.rmed.2017.06.001] [PMID: 28732835]
[http://dx.doi.org/10.1155/2019/2067353] [PMID: 30863465]
[http://dx.doi.org/10.2165/11591490-000000000-00000] [PMID: 21668038]
[http://dx.doi.org/10.1016/j.addr.2021.113918] [PMID: 34375681]
[http://dx.doi.org/10.56397/SSSH.2023.06.03]
[http://dx.doi.org/10.1016/j.jdiacomp.2023.108477] [PMID: 37121118]
[http://dx.doi.org/10.3390/diagnostics13030432] [PMID: 36766543]
[http://dx.doi.org/10.3390/tropicalmed6010008] [PMID: 33435609]
[http://dx.doi.org/10.2337/dc14-0297] [PMID: 25249670]
[http://dx.doi.org/10.1007/978-981-16-1182-7_5]
[http://dx.doi.org/10.1038/s41746-022-00606-9] [PMID: 35545657]
[http://dx.doi.org/10.1517/14740338.5.2.231] [PMID: 16503745]
[http://dx.doi.org/10.1017/ipm.2015.55] [PMID: 30115190]
[http://dx.doi.org/10.53553/JCH.v06i02.009]
[http://dx.doi.org/10.3310/hta14360] [PMID: 20646668]
[http://dx.doi.org/10.2337/diab.46.2.271] [PMID: 9000705]
[http://dx.doi.org/10.5588/ijtld.14.0956] [PMID: 26614197]
[http://dx.doi.org/10.1067/mem.2001.114314] [PMID: 11423816]
[http://dx.doi.org/10.7759/cureus.38222] [PMID: 37252492]
[http://dx.doi.org/10.1186/s12882-023-03167-5] [PMID: 37127612]
[http://dx.doi.org/10.1097/HCR.0000000000000761] [PMID: 36576423]
[http://dx.doi.org/10.7759/cureus.38339] [PMID: 37261145]
[http://dx.doi.org/10.1016/j.cytogfr.2023.02.001] [PMID: 36797117]
[http://dx.doi.org/10.1016/j.fsi.2023.108884] [PMID: 37302677]
[http://dx.doi.org/10.1016/j.intimp.2023.109738] [PMID: 36696857]
[http://dx.doi.org/10.1016/j.bcp.2023.115663] [PMID: 37336252]
[http://dx.doi.org/10.1016/j.bcp.2023.115636] [PMID: 37290598]
[http://dx.doi.org/10.1152/ajplung.00379.2022] [PMID: 36880685]
[http://dx.doi.org/10.3390/antiox12010070] [PMID: 36670932]
[http://dx.doi.org/10.3389/fphar.2023.1089812] [PMID: 36817136]
[http://dx.doi.org/10.2337/diabetes.51.7.2148] [PMID: 12086945]
[http://dx.doi.org/10.1016/j.eprac.2022.08.002] [PMID: 35963508]
[http://dx.doi.org/10.2165/00003495-199754030-00001] [PMID: 9279500]
[http://dx.doi.org/10.3389/fnins.2021.708547] [PMID: 34489627]
[http://dx.doi.org/10.1016/j.diabet.2020.07.006] [PMID: 32750451]
[http://dx.doi.org/10.2337/diabetes.53.6.1621] [PMID: 15161771]
[http://dx.doi.org/10.3390/tropicalmed7110343] [PMID: 36355885]
[http://dx.doi.org/10.1016/j.euros.2021.10.002]
[http://dx.doi.org/10.2337/diaspect.15.1.28]
[http://dx.doi.org/10.1016/j.amjmed.2009.03.015] [PMID: 19464427]
[http://dx.doi.org/10.1186/s12879-020-05473-x] [PMID: 33287713]
[http://dx.doi.org/10.1016/j.jconrel.2017.03.008] [PMID: 28279798]
[http://dx.doi.org/10.1016/S2213-8587(18)30074-3] [PMID: 30072234]
[http://dx.doi.org/10.1007/s40265-014-0222-8] [PMID: 24846578]
[http://dx.doi.org/10.1016/j.ijmyco.2013.01.004] [PMID: 29516879]
[http://dx.doi.org/10.5588/pha.16.0114] [PMID: 28695089]
[http://dx.doi.org/10.1038/s41598-017-01213-5] [PMID: 28439071]
[http://dx.doi.org/10.1128/AAC.46.2.267-274.2002] [PMID: 11796329]
[http://dx.doi.org/10.5588/ijtld.19.0186] [PMID: 32127106]
[PMID: 22771605]
[http://dx.doi.org/10.1183/09031936.00092614] [PMID: 25882805]
[http://dx.doi.org/10.5336/medsci.2019-70810]
[http://dx.doi.org/10.1111/jgh.13070] [PMID: 26243373]
[http://dx.doi.org/10.2217/bmm-2021-0121] [PMID: 34704822]
[http://dx.doi.org/10.3390/nu15020314] [PMID: 36678185]
[http://dx.doi.org/10.1016/j.hjc.2022.12.012] [PMID: 36586422]
[http://dx.doi.org/10.1016/S2213-8587(14)70110-X] [PMID: 25194887]
[http://dx.doi.org/10.1007/s11096-008-9243-2] [PMID: 18784982]
[http://dx.doi.org/10.1093/ecam/nen027] [PMID: 18955338]
[http://dx.doi.org/10.2337/dsi22-0018] [PMID: 37193203]
[http://dx.doi.org/10.3389/fimmu.2022.1084960] [PMID: 36685490]
[http://dx.doi.org/10.1016/S0272-5231(05)70012-5] [PMID: 10763094]
[http://dx.doi.org/10.1038/nm.2807] [PMID: 22772564]
[http://dx.doi.org/10.1016/j.biopha.2022.113236] [PMID: 35691154]
[http://dx.doi.org/10.2165/00002512-200118010-00003] [PMID: 11232737]
[http://dx.doi.org/10.3390/cancers15030701] [PMID: 36765659]
[http://dx.doi.org/10.1177/20499361221095831] [PMID: 35646347]
[http://dx.doi.org/10.1007/978-981-16-6395-6_14]
[http://dx.doi.org/10.1002/ebch.1962] [PMID: 25404581]