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Current HIV Research

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ISSN (Print): 1570-162X
ISSN (Online): 1873-4251

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Case Report

Differential Diagnosis or Etiology: A Case Report on Amyotrophic Lateral Sclerosis-like Neuropathy Associated with HIV Infection

Author(s): Renato Barradas Rodrigues*, Marco Orsini, Sofia Vieira Neves, Wladimir Bocca Vieira de Rezende Pinto, Antônio Marcos da Silva Catarino, Daniel Antunes Pereira and Acary Souza Bulle Oliveira

Volume 21, Issue 5, 2023

Published on: 16 October, 2023

Page: [323 - 329] Pages: 7

DOI: 10.2174/1570162X21666230914104220

Price: $65

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Abstract

Background: Retroviruses are described as a risk factor for chronic neuropathy. However, it is still unknown if they can work as amyotrophic lateral sclerosis triggers. Over the years, some cases of this association have been described with heterogenous disclosures.

Case Representation: This study aimed to report a case of HIV and ALS-like neuropathy and briefly discuss peculiarities of clinical aspects, such as physiopathology and treatment options. The patient underwent neurological examination associated with blood tests, electromyography, analysis of cerebrospinal fluid, and imaging studies.

Discussion: A non-systematic review was performed in major databases regarding the topic. The case presented mixed upper and lower motor neuron signs and was framed as a probable case of ALS following the present criteria.

Conclusion: After a short follow-up and viral load cleansing, neurological stabilization was achieved.

Keywords: Motor neuron disease, amyotrophic lateral sclerosis, HIV, anti-retroviral agents, riluzole, edaravone, DNA transposable elements, retroelements.

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