Login Register Cart 0
Generic placeholder image

Endocrine, Metabolic & Immune Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Case Report

A Case Presenting with Neck Pain and High Sedimentation Rate: Amyloid Goiter

Author(s): Puren Gokbulut*, Gonul Koc, Sevdenur Firat, Pelin Oztekin, Pinar Celepli, Seher Kökceoglu and Cavit Culha

Volume 24, Issue 9, 2024

Published on: 09 October, 2023

Page: [1120 - 1125] Pages: 6

DOI: 10.2174/1871530323666230907093422

Price: $65

Open Access Journals Promotions 2
conference banner
Abstract

Introduction: Amyloid goiter is a rare disease characterized by amyloid deposits that cause sudden growth in the thyroid gland.

Case Presentation: Here we present a case of a 26-year-old woman with euthyroid amyloid goiter who presented with subacute granulomatous thyroiditis clinic. Amyloid goiter was detected as a result of core biopsy from the thyroid parenchyma of the patient with sudden thyroid enlargement. Surgery was not applied to the patient who had no pressure symptoms or signs. In systemic amyloidosis secondary to Familial Mediterranean fever, heart and kidney involvement, as well as the thyroid gland, were detected.

Conclusion: Amyloid accumulation should be considered in addition to anaplastic thyroid cancer and lymphoma in patients with sudden thyroid enlargement. It should not be overlooked that amyloid goiter may mimic subacute thyroiditis clinic. Systemic amyloidosis should be considered in patients with amyloid goiter, and an examination should be made to assess the presence of amyloid accumulations in other organs.

Keywords: Neck Pain, amyloid goiter, familial mediterranean fever, thyroid enlargement, anaplastic thyroid cancer, amyloid accumulations.

« Previous
Graphical Abstract

[1]
Wechalekar, A.D.; Gillmore, J.D.; Hawkins, P.N. Systemic amyloidosis. Lancet, 2016, 387(10038), 2641-2654.
[http://dx.doi.org/10.1016/S0140-6736(15)01274-X] [PMID: 26719234]
[2]
Vaxman, I.; Gertz, M. When to suspect a diagnosis of amyloidosis. Acta Haematol., 2020, 143(4), 304-311.
[http://dx.doi.org/10.1159/000506617] [PMID: 32340017]
[3]
Chincholi, T.; Ahmed, T.; Kumar, Y.; Pinto, A.C.; Mallik, E.; Varghese, G.M. Rare cause of thyroid enlargement: Localized AA amyloid goiter - A case report. Int. J. Surg. Case Rep., 2022, 92, 106876.
[http://dx.doi.org/10.1016/j.ijscr.2022.106876] [PMID: 35240483]
[4]
Hasukić, Š.; Jakubovic-Cickusic, A.; Hasukić, B.; Sulejmanović, M.; Čičkušić, A. Amyloid goiter: A case report and review of the literature. Saudi J. Med. Med. Sci., 2020, 8(2), 151-155.
[http://dx.doi.org/10.4103/sjmms.sjmms_308_19] [PMID: 32587498]
[5]
Pinto, A.; Nosé, V. Localized amyloid in thyroid: Are we missing it? Adv. Anat. Pathol., 2013, 20(1), 61-67.
[http://dx.doi.org/10.1097/PAP.0b013e31827b6519] [PMID: 23232573]
[6]
Ozemir, I.A.; Bilgic, C.; Bayraktar, B.; Aslan, S.; Zemheri, E.; Yalman, H.; Yigitbasi, R. Amyloid goiter related with Crohn’s disease: A rare association: Amyloid goiter secondary to Crohn’s disease. Int. J. Surg. Case Rep., 2014, 5(8), 480-483.
[http://dx.doi.org/10.1016/j.ijscr.2014.06.004]
[7]
Hamed, G.; Heffess, C.S.; Shmookler, B.M.; Wenig, B.M. Amyloid goiter. A clinicopathologic study of 14 cases and review of the literature. Am. J. Clin. Pathol., 1995, 104(3), 306-312.
[http://dx.doi.org/10.1093/ajcp/104.3.306] [PMID: 7677120]
[8]
Siddiqui, M.A.; Gertz, M.; Dean, D. Amyloid goiter as a manifestation of primary systemic amyloidosis. Thyroid, 2007, 17(1), 77-80.
[http://dx.doi.org/10.1089/thy.2006.0045] [PMID: 17274755]
[9]
Villamil, C.F.; Massimi, G.; D’Avella, J.; Cole, S.R. Amyloid goiter with parathyroid involvement: A case report and review of the literature. Arch. Pathol. Lab. Med., 2000, 124(2), 281-283.
[http://dx.doi.org/10.5858/2000-124-0281-AGWPI] [PMID: 10656739]
[10]
Sethi, Y.; Gulati, A.; Singh, I.; Rao, S.; Singh, N. Amyloid goiter: A case of primary thyroid amyloid disease. Laryngoscope, 2011, 121(5), 961-964.
[http://dx.doi.org/10.1002/lary.21459] [PMID: 21520108]
[11]
Bakan, S.; Kandemirli, S.G.; Akbas, S.; Cingoz, M.; Ozcan Guzelbey, B.; Kantarci, F.; Akman, C. Amyloid goiter: A diagnosis to consider in diffuse fatty infiltration of the thyroid. J. Ultrasound Med., 2017, 36(5), 1045-1049.
[http://dx.doi.org/10.7863/ultra.16.04037] [PMID: 28258641]
[12]
Kimura, H.; Yamashita, S.; Ashizawa, K.; Yokoyama, N.; Nagataki, S. Thyroid dysfunction in patients with amyloid goitre. Clin. Endocrinol., 1997, 46(6), 769-774.
[http://dx.doi.org/10.1046/j.1365-2265.1997.1841000.x] [PMID: 9274710]
[13]
Celis Pinto, J.C.; Torres-Rivas, H.E.; Fernández Fernández, L.M.; Villar Zarra, K.; González Gutiérrez, M. Amyloid goiter diagnosis by ultrasound-guided fine needle aspiration performed by interventional pathologist. Diagn. Cytopathol., 2021, 49(3), E137-E140.
[http://dx.doi.org/10.1002/dc.24625] [PMID: 32970371]
[14]
Özdemir, B.H.; Uyar, P.; Özdemir, F.N. Diagnosing amyloid goitre with thyroid aspiration biopsy. Cytopathology, 2006, 17(5), 262-266.
[http://dx.doi.org/10.1111/j.1365-2303.2006.00399.x] [PMID: 16961655]
[15]
Villa, F.; Dionigi, G.; Tanda, M.L.; Rovera, F.; Boni, L. Amyloid goiter. Int. J. Surg., 2008, 6(Suppl. 1), S16-S18.
[http://dx.doi.org/10.1016/j.ijsu.2008.12.025] [PMID: 19168408]
[16]
Cannizzaro, M.A.; Lo Bianco, S.; Saliba, W.; D’Errico, S.; Pennetti Pennella, F.; Buttafuoco, G.; Provenzano, D.; Magro, G. A rare case of primary thyroid amyloidosis. Int. J. Surg. Case Rep., 2018, 53, 179-181.
[http://dx.doi.org/10.1016/j.ijscr.2018.10.033] [PMID: 30408741]

Rights & Permissions Print Cite
Article Metrics
11
2
Wayfinder Image
Open Access Journals Promotions
World Diabetes Day
© 2024 Bentham Science Publishers | Privacy Policy