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Current Drug Therapy

Editor-in-Chief

ISSN (Print): 1574-8855
ISSN (Online): 2212-3903

Review Article

An Update on the Role of Circadian Rhythms in Sleep Disorders

Author(s): Namra Aziz, Vipin Kumar Garg, Yadav Rupali Vinod, Arpit Gupta, Ankita Wal, Shruti Rathore and Pranay Wal*

Volume 19, Issue 3, 2024

Published on: 11 September, 2023

Page: [302 - 316] Pages: 15

DOI: 10.2174/1574885518666230818102714

Price: $65

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Abstract

Background: The comprehension of the molecular, cellular, and biological mechanisms that underlie the management of the sleep-wake cycle, as well as the effects of circadian disruption on health and illness, has made significant strides.

Methods: An extensive literature review was done from the standard databases such as Scopus, Elsevier, and PubMed using standard keywords “Circadian rhythm”, and “sleep disorders”. In this section, we examined circadian biology and provided adetailed description of the pathogenesis, clinical characteristics, diagnosis, and management of the most typical Circadian rhythm sleep disorders (CRSDs) seen in clinical practice.

Conclusion: It can be concluded that the central circadian rhythm mechanism may be altered, or the intrinsic circadian clock and the environment may not be in sync, to produce circadian rhythm sleep disorders. As a consequence, we must focus on modifying our way of life in a constructive and healthy way. Even while the lifestyle is based on personal preferences and identities, it is important to examine it in isolation from its sociocultural environment.

Keywords: Circadian rhythm, sleep disorders, melatonin, metabolic syndrome, circadian rhythm disruptions, pathogenesis.

Graphical Abstract
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