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Mini-Reviews in Medicinal Chemistry

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ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

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Review Article

Recent Literature on the Synthesis of Thiazole Derivatives and their Biological Activities

Author(s): Thoraya A. Farghaly*, Ghaidaa H. Alfaifi and Sobhi M. Gomha

Volume 24, Issue 2, 2024

Published on: 01 September, 2023

Page: [196 - 251] Pages: 56

DOI: 10.2174/1389557523666230726142459

Price: $65

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Abstract

The thiazole ring is naturally occurring and is primarily found in marine and microbial sources. It has been identified in various compounds such as peptides, vitamins (thiamine), alkaloids, epothilone, and chlorophyll. Thiazole-containing compounds are widely recognized for their antibacterial, antifungal, anti-inflammatory, antimalarial, antitubercular, antidiabetic, antioxidant, anticonvulsant, anticancer, and cardiovascular activities. The objective of this review is to present recent advancements in the discovery of biologically active thiazole derivatives, including their synthetic methods and biological effects. This review comprehensively discusses the synthesis methods of thiazole and its corresponding biological activities within a specific timeframe, from 2017 until the conclusion of 2022.

Keywords: Thiazoles, synthesis, biological activity, anticancer, antimicrobial, disease.

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