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Current Medical Imaging

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ISSN (Print): 1573-4056
ISSN (Online): 1875-6603

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Case Report

Prolapsed Uterine Smooth Muscle Tumor of uncertain Malignant Potential: A Case Report and Review of Radiological Findings

Author(s): Junhyeon Jeon, Jinyoung Park*, Eunjoo Lee, Jiyeon Han, Dasom Kim, Jungwon Park, Minha Kwag, Suyoung Yun and Soo Jin Jung

Volume 20, 2024

Published on: 02 August, 2023

Article ID: e140623217957 Pages: 4

DOI: 10.2174/1573405620666230614093128

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Abstract

Introduction: Uterine smooth muscle tumor of uncertain malignant potential (STUMP) is a rare tumor that arises in the myometrium of the uterus. It is regarded as an intermediate malignant tumor according to the recent World Health Organization classification. Few studies have reported the radiologic findings of STUMP, and the differentiation of STUMP from leiomyoma remains controversial.

Case Description: A 42-year-old nulliparous female presented at our institution with massive vaginal bleeding. Radiological studies, including ultrasonography, computed tomography (CT), and magnetic resonance imaging, revealed an oval-shaped mass with well-defined margins in the uterus protruding into the vagina. The patient underwent a total abdominal hysterectomy, and the final pathology was confirmed as STUMP.

Conclusion: Distinguishing STUMP from leiomyomas based solely on radiological findings can be challenging. However, if the uterine mass appears as a single mass lacking acoustic shadowing on ultrasound and demonstrates diffusion restriction with high T2 signal intensity on magnetic resonance imaging, consideration of STUMP may be necessary for proper patient management, given the poor prognosis associated with this tumor.

Keywords: Uterine smooth muscle tumor of uncertain malignant potential, STUMP, Computed tomography, Magnetic resonance imaging, Case report, Radiology, Uterus.

[1]
Picerno TM, Wasson MN, Gonzalez Rios AR, et al. Morcellation and the incidence of occult uterine malignancy: A dual-institution review. Int J Gynecol Cancer 2016; 26(1): 149-55.
[http://dx.doi.org/10.1097/IGC.0000000000000558] [PMID: 26332395]
[2]
Liu HT, Wong CN, Wong CN, Liu FS. Uterine smooth muscle tumor of uncertain malignant potential: A review of current knowledge. Taiwan J Obstet Gynecol 2022; 61(6): 935-40.
[http://dx.doi.org/10.1016/j.tjog.2022.08.003] [PMID: 36427995]
[3]
Rizzo A, Ricci AD, Saponara M, et al. Recurrent uterine smooth-muscle tumors of uncertain malignant potential (STUMP): State of the art. Anticancer Res 2020; 40(3): 1229-38.
[http://dx.doi.org/10.21873/anticanres.14064] [PMID: 32132019]
[4]
Tumours of the uterine corpus: Mesenchymal tumours. WHO classification of tumours of female reproductive organs (4th ed.). 2014. Available from: https://publications.iarc.fr/Book-And-Report-Series/Who-Classification-Of-Tumours/WHO-Classification-Of-Tumours-Of-Female-Reproductive-Organs-2014
[5]
Gadducci A, Zannoni GF. Uterine smooth muscle tumors of unknown malignant potential: A challenging question. Gynecol Oncol 2019; 154(3): 631-7.
[http://dx.doi.org/10.1016/j.ygyno.2019.07.002] [PMID: 31326137]
[6]
Ip PPC, Tse KY, Tam KF. Uterine smooth muscle tumors other than the ordinary leiomyomas and leiomyosarcomas: A review of selected variants with emphasis on recent advances and unusual morphology that may cause concern for malignancy. Adv Anat Pathol 2010; 17(2): 91-112.
[http://dx.doi.org/10.1097/PAP.0b013e3181cfb901] [PMID: 20179432]
[7]
Jiang G, Zhang L, Li G, et al. Atypical magnetic resonance imaging vs pathological findings of leiomyoma in the female reproductive system. Nan Fang Yi Ke Da Xue Xue Bao 2009; 29(2): 301-4.
[8]
Macciò A, Chiappe G, Kotsonis P, et al. Abdominal leiomyosarcomatosis after surgery with external morcellation for occult smooth muscle tumors of uncertain malignant potential: A case report. Int J Surg Case Rep 2017; 38: 107-10.
[http://dx.doi.org/10.1016/j.ijscr.2017.07.020] [PMID: 28755615]
[9]
Cotrino I, Carosso A, Macchi C, et al. Ultrasound and clinical characteristics of uterine smooth muscle tumors of uncertain malignant potential (STUMPs). Eur J Obstet Gynecol Reprod Biol 2020; 251: 167-72.
[http://dx.doi.org/10.1016/j.ejogrb.2020.05.040] [PMID: 32505056]
[10]
Atkins KA, Arronte N, Darus CJ, Rice LW. The Use of p16 in enhancing the histologic classification of uterine smooth muscle tumors. Am J Surg Pathol 2008; 32(1): 98-102.
[http://dx.doi.org/10.1097/PAS.0b013e3181574d1e] [PMID: 18162776]
[11]
Bell SW, Kempson RL, Hendrickson MR. Problematic uterine smooth muscle neoplasms. A clinicopathologic study of 213 cases. Am J Surg Pathol 1994; 18(6): 535-58.
[http://dx.doi.org/10.1097/00000478-199406000-00001] [PMID: 8179071]
[12]
Zheng Y-Y, Liu XB, Mao YY, Lin MH. Smooth muscle tumor of uncertain malignant potential (STUMP): A clinicopathologic analysis of 26 cases. Int J Clin Exp Pathol 2020; 13(4): 818-26.
[PMID: 32355532]
[13]
Dall’Asta A, Gizzo S, Musarò A, et al. Uterine smooth muscle tumors of uncertain malignant potential (STUMP): Pathology, follow-up and recurrence. Int J Clin Exp Pathol 2014; 7(11): 8136-42.
[PMID: 25550862]
[14]
Ip PPC, Cheung ANY, Clement PB. Uterine smooth muscle tumors of uncertain malignant potential (STUMP): A clinicopathologic analysis of 16 cases. Am J Surg Pathol 2009; 33(7): 992-1005.
[http://dx.doi.org/10.1097/PAS.0b013e3181a02d1c] [PMID: 19417585]
[15]
Amant F, Coosemans A, Debiec-Rychter M, Timmerman D, Vergote I. Clinical management of uterine sarcomas. Lancet Oncol 2009; 10(12): 1188-98.
[http://dx.doi.org/10.1016/S1470-2045(09)70226-8] [PMID: 19959075]
[16]
Bonneau C, Thomassin-Naggara I, Dechoux S, Cortez A, Darai É, Rouzier R. Value of ultrasonography and magnetic resonance imaging for the characterization of uterine mesenchymal tumors. Acta Obstet Gynecol Scand 2014; 93(3): 261-8.
[http://dx.doi.org/10.1111/aogs.12325] [PMID: 24372487]
[17]
Tasaki A, Asatani MO, Umezu H, et al. Differential diagnosis of uterine smooth muscle tumors using diffusion-weighted imaging: Correlations with the apparent diffusion coefficient and cell density. Abdom Imaging 2015; 40(6): 1742-52.
[http://dx.doi.org/10.1007/s00261-014-0324-5] [PMID: 25526683]

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