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CNS & Neurological Disorders - Drug Targets

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ISSN (Print): 1871-5273
ISSN (Online): 1996-3181

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One-Trial Appetitive Learning Tasks for Drug Targeting

Author(s): Robert Lalonde* and Catherine Strazielle

Volume 23, Issue 6, 2024

Published on: 15 June, 2023

Page: [680 - 686] Pages: 7

DOI: 10.2174/1871527322666230607152758

Price: $65

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Abstract

One-trial appetitive learning developed from one-trial passive avoidance learning as a standard test of retrograde amnesia. It consists of one learning trial followed by a retention test, in which physiological manipulations are presented. As in passive avoidance learning, food- or waterdeprived rats or mice finding food or water inside an enclosure are vulnerable to the retrograde amnesia produced by electroconvulsive shock treatment or the injection of various drugs. In one-trial taste or odor learning conducted in rats, birds, snails, bees, and fruit flies, there is an association between a food item or odorant and contextual stimuli or the unconditioned stimulus of Pavlovian conditioning. The odor-related task in bees was sensitive to protein synthesis inhibition as well as cholinergic receptor blockade, both analogous to results found on the passive avoidance response in rodents, while the task in fruit flies was sensitive to genetic modifications and aging, as seen in the passive avoidance response of genetically modified and aged rodents. These results provide converging evidence of interspecies similarities underlying the neurochemical basis of learning.

Keywords: Instrumental learning, pavlovian conditioning, food motivation, water motivation, electroconvulsive shock, cholinergic receptors, retrograde amnesia.

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