The Potential of Nanotechnology to Replace Cancer Stem Cells

Muhammad   Ammar   Amanat; Anum      Farrukh; Muhammad   Umer Bin Muhammad   Ishaq; Binyameen      Bin Shafqat; Saqib   Hussain   Haidri; Rehab      Amin; Rafia      Sameen; Tahira      Kamal; Muhammad   Naeem   Riaz; Waleed      Quresh; Rabia      Ikram; Ghulam   Muhammad   Ali; Sania      Begum; Sajid   Ali Khan   Bangash; Imdad      Kaleem; Shahid      Bashir; Sahir   Hameed   Khattak

doi:10.2174/1574888X18666230601140700

Abstract

Stem cells, which were initially identified in the 1900s, are distinct cells with the potential to replenish themselves as well as differentiate into specialised cells with certain forms and functions. Cancer stem cells play a significant role in the growth and recurrence of the tumours and, similar to normal stem cells, are capable of proliferating and differentiating. Traditional cancer treatments are ineffective against cancer stem cells, which leads to tumour regrowth. Cancer stem cells are thought to emerge as a result of epithelial-to-mesenchymal transition pathways. Brain, prostate, pancreatic, blood, ovarian, lung, liver, melanomas, AML, and breast cancer stem cells are among the most prevalent cancer forms. This review aims to comprehend the possibility of using specific forms of nanotechnology to replace cancer stem cells. In terms of nanotechnology, magnetic nanoparticles can deliver medications, especially to the target region without harming healthy cells, and they are biocompatible. In order to kill glioma cancer stem cells, the gold nanoparticles bond with DNA and function as radio sensitizers. In contrast, liposomes can circulate and traverse biological membranes and exhibit high therapeutic efficacy, precise targeting, and better drug release. Similar to carbon nanotubes, grapheme, and grapheme oxide, these substances can be delivered specifically when utilized in photothermal therapy. Recent treatments including signaling pathways and indicators targeted by nanoparticles are being researched. Future research in nanotechnology aims to develop more effective and targeted medicinal approaches. The results of the current investigation also showed that this technology's utilization will improve medical therapy and treatment.

Keywords: Cancer stem cells, nanomaterials, nanotechnology, gold nano-particles, carbon nano-tubes, grapheme, and grapheme oxide.

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[1]
Sachin K, Singh NP. Stem cells: A new paradigm. Indian Journal of Human Genetics  2006; 12(1): 4-10.
 [http://dx.doi.org/10.4103/0971-6866.25295]

[2]
Kalra K, Tomar P. Stem cell: Basics, classification and applications. Am J Phytomed Clin Therapeut  2014; 2(7): 919-30.

[3]
Singh VK, Saini A, Chandra R. The implications and future perspectives of nanomedicine for cancer stem cell targeted therapies. Front Mol Biosci  2017; 4: 52.
 [http://dx.doi.org/10.3389/fmolb.2017.00052] [PMID:  28785557]

[4]
Kobayashi NCC, Noronha SMR. Cancer stem cells: A new approach to tumor development. Rev Assoc Med Bras  2015; 61(1): 86-93.
 [http://dx.doi.org/10.1590/1806-9282.61.01.086] [PMID:  25909215]

[5]
Parada LF, Dirks PB, Wechsler-Reya RJ. Brain tumor stem cells remain in play. J Clin Oncol  2017; 35(21): 2428-31.
 [http://dx.doi.org/10.1200/JCO.2017.73.9540] [PMID:  28640710]

[6]
Kim JJ, Tannock IF. Repopulation of cancer cells during therapy: An important cause of treatment failure. Nat Rev Cancer  2005; 5(7): 516-25.
 [http://dx.doi.org/10.1038/nrc1650] [PMID:  15965493]

[7]
Qin W, Huang G, Chen Z, Zhang Y. Nanomaterials in targeting cancer stem cells for cancer therapy. Front Pharmacol  2017; 8: 1.
 [http://dx.doi.org/10.3389/fphar.2017.00001] [PMID:  28149278]

[8]
Pattabiraman DR, Weinberg RA. Tackling the cancer stem cells — what challenges do they pose? Nat Rev Drug Discov  2014; 13(7): 497-512.
 [http://dx.doi.org/10.1038/nrd4253] [PMID:  24981363]

[9]
Lytle NK, Barber AG, Reya T. Stem cell fate in cancer growth, progression and therapy resistance. Nat Rev Cancer  2018; 18(11): 669-80.
 [http://dx.doi.org/10.1038/s41568-018-0056-x] [PMID:  30228301]

[10]
Chang JC. (2016). Cancer stem cells: Role in tumor growth, recurrence, metastasis, and treatment resistance. Medicine  95(1S): S20-5.
 [http://dx.doi.org/10.1097/MD.0000000000004766]

[11]
Farokhzad OC, Cheng J, Teply BA, et al. Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo. Proc Natl Acad Sci USA  2006; 103(16): 6315-20.
 [http://dx.doi.org/10.1073/pnas.0601755103] [PMID:  16606824]

[12]
Hong I-S, Jang GB, Lee HY, Nam JS. Targeting cancer stem cells by using the nanoparticles. Int J Nanomedicine  2015; 10: 251-60.
 [PMID:  26425092]

[13]
Lu B, Huang X, Mo J, Zhao W. Drug delivery using nanoparticles for cancer stem-like cell targeting. Front Pharmacol  2016; 7: 84.
 [http://dx.doi.org/10.3389/fphar.2016.00084] [PMID:  27148051]

[14]
Clarke MF, Hass AT.  Cancer stem cells. Reviews in cell biology and molecular medicine.  2006. R.A. Meyers (Ed.).
 [http://dx.doi.org/10.1002/3527600906.mcb.200300130]

[15]
Santilli G, Binda M, Zaffaroni N, Daidone MG. Breast cancer-initiating cells: insights into novel treatment strategies. Cancers (Basel)  2011; 3(1): 1405-25.
 [http://dx.doi.org/10.3390/cancers3011405] [PMID:  24212666]

[16]
Facchino S, Abdouh M, Bernier G. Brain cancer stem cells: current status on glioblastoma multiforme. Cancers (Basel)  2011; 3(2): 1777-97.
 [http://dx.doi.org/10.3390/cancers3021777] [PMID:  24212782]

[17]
Qureshi IA, Mehler MF. Epigenetics, nervous system tumors, and cancer stem cells. Cancers (Basel)  2011; 3(3): 3525-56.
 [http://dx.doi.org/10.3390/cancers3033525] [PMID:  24212967]

[18]
Mitra D, Malkoski SP, Wang XJ. Cancer stem cells in head and neck cancer. Cancers (Basel)  2011; 3(1): 415-27.
 [http://dx.doi.org/10.3390/cancers3010415] [PMID:  24212622]

[19]
Simeone DM. Pancreatic cancer stem cells: Implications for the treatment of pancreatic cancer. Clin Cancer Res  2008; 14(18): 5646-8.
 [http://dx.doi.org/10.1158/1078-0432.CCR-08-0584] [PMID:  18794070]

[20]
Kryczek I, Liu S, Roh M, et al. Expression of aldehyde dehydrogenase and CD133 defines ovarian cancer stem cells. Int J Cancer  2012; 130(1): 29-39.
 [http://dx.doi.org/10.1002/ijc.25967] [PMID:  21480217]

[21]
Todaro M, Alea MP, Di Stefano AB, et al. Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4. Cell Stem Cell  2007; 1(4): 389-402.
 [http://dx.doi.org/10.1016/j.stem.2007.08.001] [PMID:  18371377]

[22]
Zhao Y, Alakhova DY, Kabanov AV. Can nanomedicines kill cancer stem cells? Adv Drug Deliv Rev  2013; 65(13-14): 1763-83.
 [http://dx.doi.org/10.1016/j.addr.2013.09.016] [PMID:  24120657]

[23]
Zhao Y, Zhao W, Lim YC, Liu T. Salinomycin-loaded gold nanoparticles for treating cancer stem cells by ferroptosis-induced cell death. Mol Pharm  2019; 16(6): 2532-9.
 [http://dx.doi.org/10.1021/acs.molpharmaceut.9b00132] [PMID:  31009228]

[24]
Jamil K, Khattak SH, Farrukh A, et al. Biogenic synthesis of silver nanoparticles using Catharanthus roseus and its cytotoxicity effect on vero cell lines. Molecules  2022; 27(19): 6191.
 [http://dx.doi.org/10.3390/molecules27196191] [PMID:  36234756]

[25]
Rasmussen JW, Martinez E, Louka P, Wingett DG. Zinc oxide nanoparticles for selective destruction of tumor cells and potential for drug delivery applications. Expert Opin Drug Deliv  2010; 7(9): 1063-77.
 [http://dx.doi.org/10.1517/17425247.2010.502560] [PMID:  20716019]

[26]
Mohammed ZF, Hammad M, AL-dulaimi M. Synthesis of Nano Sulfur particles and their Antitumor activity. Biochem Lett  2018; 14(1): 109-28.
 [http://dx.doi.org/10.21608/blj.2018.47589]

[27]
Davis Mark E, Zhuo Chen, Shin Dong M. Nanoparticle therapeutics: an emerging treatment modality for cancer. Nanoscience And Technology: A Collection of Reviews from Nature Journals  2010; 239-50.

[28]
Jain S, Hirst D, O'sullivan JJTBjor. Gold nanoparticles as novel agents for cancer therapy. Br J Radiol  2012; 85(1010): 101-13.
 [http://dx.doi.org/10.1259/bjr/59448833]

[29]
Biserova K, Jakovlevs A, Uljanovs R, Strumfa I. Cancer Stem Cells: Significance in origin, pathogenesis and treatment of glioblastoma. Cells  2021; 10(3): 621.
 [http://dx.doi.org/10.3390/cells10030621] [PMID:  33799798]

[30]
Sun TM, Wang YC, Wang F, et al. Cancer stem cell therapy using doxorubicin conjugated to gold nanoparticles via hydrazone bonds 2014; 35(2): 836-45.
 [http://dx.doi.org/10.1016/j.biomaterials.2013.10.011]

[31]
Satapathy SR, et al. Metallic gold and bioactive quinacrine hybrid nanoparticles inhibit oral cancer stem cell and angiogenesis by deregulating inflammatory cytokines in p53 dependent manner 2018; 14(3): 883-96.
 [http://dx.doi.org/10.1016/j.nano.2018.01.007]

[32]
Dziawer L, Koźmiński P, Męczyńska-Wielgosz S, et al. Gold nanoparticle bioconjugates labelled with 211 At for targeted alpha therapy. RSC Advances  2017; 7(65): 41024-32.
 [http://dx.doi.org/10.1039/C7RA06376H]

[33]
Zhang Y, Li M, Gao X, Chen Y, Liu T. Nanotechnology in cancer diagnosis: progress, challenges and opportunities. J Hematol Oncol  2019; 12(1): 137.
 [http://dx.doi.org/10.1186/s13045-019-0833-3] [PMID:  31847897]

[34]
Maherani B, Arab-Tehrany E, R Mozafari M, Gaiani C, Linder M. Liposomes: a review of manufacturing techniques and targeting strategies 2011; 7(3): 436-52.
 [http://dx.doi.org/10.2174/157341311795542453]

[35]
Sun X, Chen Y, Zhao H, et al. Dual-modified cationic liposomes loaded with paclitaxel and survivin siRNA for targeted imaging and therapy of cancer stem cells in brain glioma 2018; 25(1): 1718-27.
 [http://dx.doi.org/10.1080/10717544.2018.1494225]

[36]
Cao J, Li C, Wei X, et al. Selective targeting and eradication of LGR5+ CSCs using RSPO conjugated doxorubicin liposomes. Molecular cancer therapeutics  2018; 17(7): 1475-85.

[37]
Zhang L, Yao HJ, Yu Y, et al. Mitochondrial targeting liposomes incorporating daunorubicin and quinacrine for treatment of relapsed breast cancer arising from cancer stem cells 2012; 33(2): 565-82.
 [http://dx.doi.org/10.1016/j.biomaterials.2011.09.055]

[38]
Inamura K, Komizu Y, Yamakuchi M, Ishida S, Matsumoto Y, Matsushita T. Inhibitory effect of hybrid liposomes on the growth of liver cancer stem cells. Biochem Biophys Res Commun  2019; 509(1): 268-74.
 [http://dx.doi.org/10.1016/j.bbrc.2018.12.118] [PMID:  30583860]

[39]
Guo J, Lu W-LJJoP, Sciences P. Effects of stealth liposomal daunorubicin plus tamoxifen on the breast cancer and cancer stem cells. 2010; 13(2): 136-51.
 [http://dx.doi.org/10.18433/J3P88Z]

[40]
Indira T, Lakshmi P. Magnetic nanoparticles—a review. Int J Pharm Sci Nanotechnol  2010; 3(3): 1035-42.

[41]
Goya G, Grazu V, Ibarra M. Magnetic nanoparticles for cancer therapy. Curr Nanosci  2008; 4(1): 1-16.
 [http://dx.doi.org/10.2174/157341308783591861]

[42]
Hao R, Xing R, Xu Z, Hou Y, Gao S, Sun S. Synthesis, functionalization, and biomedical applications of multifunctional magnetic nanoparticles. Adv Mater  2010; 22(25): 2729-42.
 [http://dx.doi.org/10.1002/adma.201000260] [PMID:  20473985]

[43]
Arruebo M, Fernández-Pacheco R, Ibarra MR, Santamaría J. Magnetic nanoparticles for drug delivery. Nano Today  2007; 2(3): 22-32.
 [http://dx.doi.org/10.1016/S1748-0132(07)70084-1]

[44]
Mornet S, Vasseur S, Grasset F, Duguet E. Magnetic nanoparticle design for medical diagnosis and therapy. J Mater Chem  2004; 14(14): 2161-75.
 [http://dx.doi.org/10.1039/b402025a]

[45]
Chomoucka J, Drbohlavova J, Huska D, Adam V, Kizek R, Hubalek J. Magnetic nanoparticles and targeted drug delivering. Pharmacol Res  2010; 62(2): 144-9.
 [http://dx.doi.org/10.1016/j.phrs.2010.01.014] [PMID:  20149874]

[46]
Xu C, Xie J, Ho D, et al. Au-Fe3O4 dumbbell nanoparticles as dual-functional probes. Angew Chem Int Ed  2008; 47(1): 173-6.
 [http://dx.doi.org/10.1002/anie.200704392] [PMID:  17992677]

[47]
Banerjee D, Harfouche R, Sengupta S. Nanotechnology-mediated targeting of tumor angiogenesis. Vasc Cell  2011; 3(1): 3.
 [http://dx.doi.org/10.1186/2045-824X-3-3] [PMID:  21349160]

[48]
Liu Z, Kiessling F, Gätjens J. Advanced nanomaterials in multimodal imaging: design, functionalization, and biomedical applications. J Nanomater  2010; 2010: 1-15.
 [http://dx.doi.org/10.1155/2010/894303]

[49]
Hosseini A, Sharifzadeh M, Rezayat SM, et al. Benefit of magnesium-25 carrying porphyrin-fullerene nanoparticles in experimental diabetic neuropathy. Int J Nanomedicine  2010; 5: 517-23.
 [PMID:  20957114]

[50]
Zhao D, Zhao X, Zu Y, et al. Preparation, characterization, and in vitro targeted delivery of folate-decorated paclitaxel-loaded bovine serum albumin nanoparticles. Int J Nanomedicine  2010; 5: 669-77.
 [PMID:  20957218]

[51]
Rao W, Wang H, Zhong A, Yu J, Lu X, He X. Nanodrug-mediated thermotherapy of cancer stem-like cells. J Nanosci Nanotechnol  2016; 16(3): 2134-42.
 [http://dx.doi.org/10.1166/jnn.2016.10942] [PMID:  27455612]

[52]
Liu Z, Robinson JT, Tabakman SM, Yang K, Dai H. Carbon materials for drug delivery & cancer therapy. Mater Today  2011; 14(7-8): 316-23.
 [http://dx.doi.org/10.1016/S1369-7021(11)70161-4]

[53]
Zhang W, Zhang Z, Zhang Y. The application of carbon nanotubes in target drug delivery systems for cancer therapies. Nanoscale Res Lett  2011; 6(1): 555.
 [http://dx.doi.org/10.1186/1556-276X-6-555] [PMID:  21995320]

[54]
Sun T-P, Shieh HL, Ching CT, et al. Carbon nanotube composites for glucose biosensor incorporated with reverse iontophoresis function for noninvasive glucose monitoring. Int J Nanomedicine  2010; 5: 343-9.
 [PMID:  20517479]

[55]
Cui D, Zhang H, Sheng J, et al. Effects of CdSe/ZnS quantum dots covered multi-walled carbon nanotubes on murine embryonicstem cells. Nano Biomed Eng  2010; 2(4): 236-44.
 [http://dx.doi.org/10.5101/nbe.v2i4.p236-244]

[56]
Pitroda J, Jethwa B, Dave SK. A critical review on carbon nanotubes. Int J Constr Res Civ Eng  2016; 2(5): 36-42.

[57]
Singh R, Deshmukh R. Carbon nanotube as an emerging theranostic tool for oncology. J Drug Deliv Sci Technol  2022; 74: 103586.
 [http://dx.doi.org/10.1016/j.jddst.2022.103586]

[58]
Januszewski A, Stebbing J. Hyperthermia in cancer: is it coming of age? Lancet Oncol  2014; 15(6): 565-6.
 [http://dx.doi.org/10.1016/S1470-2045(14)70207-4] [PMID:  24807858]

[59]
He X. Thermostability of biological systems: fundamentals, challenges, and quantification. Open Biomed Eng J  2011; 5(1): 47-73.
 [http://dx.doi.org/10.2174/1874120701105010047] [PMID:  21769301]

[60]
Qin Z, Bischof JC. Thermophysical and biological responses of gold nanoparticle laser heating. Chem Soc Rev  2012; 41(3): 1191-217.
 [http://dx.doi.org/10.1039/C1CS15184C] [PMID:  21947414]

[61]
Iancu C, Mocan L. Advances in cancer therapy through the use of carbon nanotube-mediated targeted hyperthermia. Int J Nanomedicine  2011; 6: 1675-84.
 [http://dx.doi.org/10.2147/IJN.S23588] [PMID:  21904457]

[62]
Kam NWS, O’Connell M, Wisdom JA, Dai H. Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction. Proc Natl Acad Sci USA  2005; 102(33): 11600-5.
 [http://dx.doi.org/10.1073/pnas.0502680102] [PMID:  16087878]

[63]
Wang CH, Chiou SH, Chou CP, Chen YC, Huang YJ, Peng CA. Photothermolysis of glioblastoma stem-like cells targeted by carbon nanotubes conjugated with CD133 monoclonal antibody. Nanomedicine  2011; 7(1): 69-79.
 [http://dx.doi.org/10.1016/j.nano.2010.06.010] [PMID:  20620237]

[64]
Burke AR, Singh RN, Carroll DL, et al. The resistance of breast cancer stem cells to conventional hyperthermia and their sensitivity to nanoparticle-mediated photothermal therapy. Biomaterials  2012; 33(10): 2961-70.
 [http://dx.doi.org/10.1016/j.biomaterials.2011.12.052] [PMID:  22245557]

[65]
Dong H, Dong C, Ren T, Li Y, Shi D. Surface-engineered graphene-based nanomaterials for drug delivery. J Biomed Nanotechnol  2014; 10(9): 2086-106.
 [http://dx.doi.org/10.1166/jbn.2014.1989] [PMID:  25992450]

[66]
Robinson JT, Tabakman SM, Liang Y, et al. Ultrasmall reduced graphene oxide with high near-infrared absorbance for photothermal therapy. J Am Chem Soc  2011; 133(17): 6825-31.
 [http://dx.doi.org/10.1021/ja2010175] [PMID:  21476500]

[67]
Akhavan O, Ghaderi E, Akhavan A. Size-dependent genotoxicity of graphene nanoplatelets in human stem cells. Biomaterials  2012; 33(32): 8017-25.
 [http://dx.doi.org/10.1016/j.biomaterials.2012.07.040] [PMID:  22863381]

[68]
Yao H, Zhang Y, Sun L, Liu Y. The effect of hyaluronic acid functionalized carbon nanotubes loaded with salinomycin on gastric cancer stem cells. Biomaterials  2014; 35(33): 9208-23.
 [http://dx.doi.org/10.1016/j.biomaterials.2014.07.033] [PMID:  25115788]

[69]
Nakamura K, Iinuma H, Aoyagi Y, Shibuya H, Watanabe T. Predictive value of cancer stem-like cells and cancer-associated genetic markers for peritoneal recurrence of colorectal cancer in patients after curative surgery. Oncology  2010; 78(5-6): 309-15.
 [http://dx.doi.org/10.1159/000318862] [PMID:  20616575]

[70]
Li R, Wu R, Zhao L, Wu M, Yang L, Zou H. P-glycoprotein antibody functionalized carbon nanotube overcomes the multidrug resistance of human leukemia cells. ACS Nano  2010; 4(3): 1399-408.
 [http://dx.doi.org/10.1021/nn9011225] [PMID:  20148593]

[71]
Wu H, Shi H, Zhang H, et al. Prostate stem cell antigen antibody-conjugated multiwalled carbon nanotubes for targeted ultrasound imaging and drug delivery. Biomaterials  2014; 35(20): 5369-80.
 [http://dx.doi.org/10.1016/j.biomaterials.2014.03.038] [PMID:  24709520]

[72]
Sotropa RMB. The advantages and disadvantages of nanotechnology. Romanian J Oral Rehab  2018; 10(2): 1-8.

[73]
Alok A, Kishore M, Panat S, Upadhyay N, Agarwal N, Aggarwal A. Nanotechnology: A boon in oral cancer diagnosis and therapeutics. SRM J Res Dental Sci  2013; 4(4): 154-60.
 [http://dx.doi.org/10.4103/0976-433X.125591]

[74]
Imdad K, Abualait T, Kanwal A, et al. The metabolic role of ketogenic diets in treating epilepsy. Nutrients  2022; 14(23): 5074.
 [http://dx.doi.org/10.3390/nu14235074] [PMID:  36501104]

[75]
Patwekar M, Patwekar F, Alghamdi S, et al. Vancomycin as an Antibacterial Agent Capped with Silver Nanoparticles: An Experimental Potential Analysis. BioMed Research International  2022; 1-14.

[76]
Shinde MU, Patwekar M, Patwekar F, et al. Nanomaterials: a potential hope for life sciences from bench to bedside. Journal of Nanomaterials  2022; 2-15.

[77]
Taifa S, Muhee A, Bhat RA, Nabi SU, Roy A, Rather GA, et al. Evaluation of therapeutic efficacy of copper nanoparticles in staphylococcus aureus-induced rat mastitis model. Journal of Nanomaterials  2022; 7124114.

[78]
Farrukh A, Khattak SH, Kaleem I, et al. Plant Based Nanotechnology – A New Trend in Therapeutic Approaches of Diabetes. Endo & Diab Opn Acc J  2022; 1(1): 21-33.

[79]
Bangash SAK, Khan MS, Ambreen SH. Khattak and A.N. Siddique. Genetic transformation of Brassica juncea with antimicrobial wasabi defensin gene. Pak J Bot  2013; 45(3): 993-8.

[80]
Khattak SH, Begum S, Aqeel M, et al. Investigating the allelic variation of loci controlling rust resistance genes in wheat (Triticum aestivum L.) land races by ssr marker. Appl Ecol Environ Res  2020; 18(6): 8091-118.
 [http://dx.doi.org/10.15666/aeer/1806_80918118]

[81]
Rehman MA, Saleem R, Hasan SW, et al. Economic assessment of cereal -legume intercropping system, a way forward for improving productivity and sustaining soil health. IJBPAS  2020; 9(5): 1078-89.

[82]
Siddiqui NR, Muhammad A, Khan MR, Ali GM. Differential gene expression of pectin esterase and changes in pectin during development and ripening stages of fruit in selected cultivars of banana. Food Sci Technol  2020; 40: 827-31.

[83]
Bangash SAK, Khan MS, Ambreen SH. Khattak, A.N Siddique. Genetic transformation of Brassica juncea with antimicrobial wasabi defensin gene. Pak J Bot  2013; 45(3): 993-8.

[84]
Khattak SH, Imdad K, Anum F, et al. Fruit Ripening Characterization and Amylase Mystery in Bananas. 2022; 4(1): 33-46.
 [http://dx.doi.org/10.33552/GJNFS.2022.04.000577]

[85]
Begum S, Khattak SH, Shahzad A, et al. Molecular characterization of Pakistani wheat genotypes for leaf rust resistance. J Pure Appl Agric  2019; 4(1): 1-10.

[86]
Qaiser R, Akram Z, Asad S, et al. Genome-wide association mapping and population structure for stripe rust in Pakistani wheat germplasm. Pak J Bot  2022; 54(4): 1405-16.
 [http://dx.doi.org/10.30848/PJB2022-4(11)]

[87]
Gavas S, Quazi S, Karpiński TM. Nanoparticles for cancer therapy: Current progress and challenges. Nanoscale Res Lett  2021; 16(1): 173.
 [http://dx.doi.org/10.1186/s11671-021-03628-6] [PMID:  34866166]

[88]
Huo Y, Yu J, and Gao S. Magnetic nanoparticle-based cancer therapy. In Synthesis and biomedical applications of magnetic nanomaterials.  EDP Sciences 2022; pp. 261-90.

[89]
Manescu Paltanea V, Paltanea G, Antoniac I, Vasilescu M. Magnetic nanoparticles used in oncology. Materials (Basel)  2021; 14(20): 5948.
 [http://dx.doi.org/10.3390/ma14205948] [PMID:  34683540]

[90]
Hoang Thi T, Nguyen Tran DH, Bach L, et al. Functional Magnetic Core-Shell System-Based Iron Oxide Nanoparticle Coated with Biocompatible Copolymer for Anticancer Drug Delivery. Pharmaceutics  2019; 11(3): 120.
 [http://dx.doi.org/10.3390/pharmaceutics11030120] [PMID:  30875948]

[91]
Din F, Aman W, Ullah I, et al. Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors. Int J Nanomedicine  2017; 12: 7291-309.
 [http://dx.doi.org/10.2147/IJN.S146315]

[92]
Dahaghin A, Emadiyanrazavi S, Salimibani M, et al. A numerical investigation into the magnetic nanoparticles hyperthermia cancer treatment injection strategies. Biocybern Biomed Eng  2021; 41(2): 516-26.
 [http://dx.doi.org/10.1016/j.bbe.2021.04.002]

[93]
Dash BS, Jose G, Lu YJ, Chen JP. Functionalized reduced graphene oxide as a versatile tool for cancer therapy. Int J Mol Sci  2021; 22(6): 2989.
 [http://dx.doi.org/10.3390/ijms22062989] [PMID:  33804239]

[94]
Yuan YG, Zhang S, Hwang JY, Kong IK. Silver nanoparticles potentiates cytotoxicity and apoptotic potential of camptothecin in human cervical cancer cells. Oxid Med Cell Longev  2018; 2018: 1-21.
 [http://dx.doi.org/10.1155/2018/6121328] [PMID:  30647812]

[95]
Pei X, Zhu Z, Gan Z, et al. PEGylated nano-graphene oxide as a nanocarrier for delivering mixed anticancer drugs to improve anticancer activity. Sci Rep  2020; 10(1): 2717.
 [http://dx.doi.org/10.1038/s41598-020-59624-w] [PMID:  32066812]

[96]
Wang Y, Qiu M, Won M, et al. Emerging 2D material-based nanocarrier for cancer therapy beyond graphene. Coord Chem Rev  2019; 400: 213041.
 [http://dx.doi.org/10.1016/j.ccr.2019.213041]

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DOI https://dx.doi.org/10.2174/1574888X18666230601140700	Print ISSN 1574-888X
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The Potential of Nanotechnology to Replace Cancer Stem Cells

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