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CNS & Neurological Disorders - Drug Targets

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ISSN (Online): 1996-3181

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Review Article

Therapeutic Viewpoint on Rat Models of Locomotion Abnormalities and Neurobiological Indicators in Parkinson's Disease

Author(s): Rishabh Chaudhary* and Randhir Singh*

Volume 23, Issue 4, 2024

Published on: 09 June, 2023

Page: [488 - 503] Pages: 16

DOI: 10.2174/1871527322666230518111323

Price: $65

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Abstract

Background: Locomotion problems in Parkinson's syndrome are still a research and treatment difficulty. With the recent introduction of brain stimulation or neuromodulation equipment that is sufficient to monitor activity in the brain using electrodes placed on the scalp, new locomotion investigations in patients having the capacity to move freely have sprung up.

Objective: This study aimed to find rat models and locomotion-connected neuronal indicators and use them all over a closed-loop system to enhance the future and present treatment options available for Parkinson’s disease.

Methods: Various publications on locomotor abnormalities, Parkinson's disease, animal models, and other topics have been searched using several search engines, such as Google Scholar, Web of Science, Research Gate, and PubMed.

Results: Based on the literature, we can conclude that animal models are used for further investigating the locomotion connectivity deficiencies of many biological measuring devices and attempting to address unanswered concerns from clinical and non-clinical research. However, translational validity is required for rat models to contribute to the improvement of upcoming neurostimulation-based medicines. This review discusses the most successful methods for modelling Parkinson’s locomotion in rats.

Conclusion: This review article has examined how scientific clinical experiments lead to localised central nervous system injuries in rats, as well as how the associated motor deficits and connection oscillations reflect this. This evolutionary process of therapeutic interventions may help to improve locomotion- based treatment and management of Parkinson's syndrome in the upcoming years.

Keywords: Parkinson’s disease, locomotion abnormalities, animal models, neurobiological indicators, therapeutic options, neurotoxin 6-hydroxydopamine, pedunculopontine nucleus, alpha-synuclein.

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