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Review Article

癌症中的mTOR信号通路和mTOR抑制剂:新一代抑制剂和方法

卷 24, 期 4, 2024

发表于: 31 May, 2023

页: [478 - 494] 页: 17

弟呕挨: 10.2174/1566524023666230509161645

价格: $65

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摘要

mTOR是一种丝氨酸/苏氨酸激酶，在细胞生长、增殖和代谢中发挥多种作用。癌症中的mTOR信号变得不规则。因此，针对mTOR的药物被开发出来。虽然mTOR抑制剂雷帕霉素和雷帕霉素雷帕洛斯(依维莫司、雷帕霉素、替西莫司、去福莫司等)以及新一代mTOR抑制剂(Rapalink、Dual PI3K/mTOR抑制剂等)被用于癌症治疗，但mTOR耐药机制可能会抑制这些药物的疗效。因此，新的抑制方法被开发出来。虽然这些新的抑制方法尚未在癌症治疗中得到广泛研究，但纳米颗粒的使用已被评估为几种癌症的新治疗选择。本文综述了mTOR在肿瘤过程中的作用、耐药机制以及mTOR抑制剂在肿瘤治疗中的效果。此外，它还讨论了下一代mTOR抑制剂和使用纳米颗粒创建的抑制策略。由于mTOR耐药机制阻碍了用于癌症治疗的mTOR抑制剂的作用，因此应该开发新的抑制策略。抑制方法是使用纳米颗粒创建的，其中一种有希望的治疗选择有证据支持其有效性。

关键词: mTOR, mTOR抑制剂，癌症，耐药机制，纳米颗粒，下一代抑制剂，方法。

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