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Current Cancer Drug Targets

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Mini-Review Article

Traditional Chinese Medicine Targeting Sarcoma Virus Oncogene-related Diseases

Author(s): Yiying Wang, Xiaoyu Wang*, Kexin Su and Yifu Yang

Volume 23, Issue 10, 2023

Published on: 19 May, 2023

Page: [751 - 763] Pages: 13

DOI: 10.2174/1568009623666230426093244

Price: $65

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Abstract

The sarcoma virus oncogene (Src) tyrosine kinase, a nonreceptor protein-tyrosine kinase, plays a crucial role in cell survival, migration, differentiation and proliferation. The study of Src has developed considerably since it was first discovered as a proto-oncogene. Src has also been associated with inflammation and bone-related diseases. Src inhibitors (bosutinib, ponatinib, dasatinib, and vandetanib) have been put into clinical use. However, their side effects and cardiovascular toxicity may be a concern. There is an urgent need to explore new Src inhibitors. Traditional Chinese medicine (TCM), which has a vast history, can provide a broad resource base. Many natural compounds and TCM extracts have the potential for anti-Src treatment. This article describes the natural compounds and extracts from TCM.

Keywords: c-Src, natural compounds, traditional chinese medicine, cancer, inflammation, osteoblast.

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