摘要
腺苷及其类似物在动物细胞中作为代谢过程的生物调节剂发挥重要作用，通过嘌呤能信号系统影响多种代谢功能。本文研究了一些已知的含手性取代基嘌呤核苷的合成及其构效关系。由于这些化合物对嘌呤能信号系统受体的选择性增强，它们作为靶向治疗癌症、代谢功能障碍和神经疾病的药物原型具有很大的潜力。含有手性取代基的腺苷和鸟苷衍生物也具有抗病毒活性。
关键词: 腺苷受体，嘌呤能信号，腺苷，手性，对映体，抗病毒，转糖基化，酶。
Call for Papers in Thematic Issues
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The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
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