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Current Medical Imaging

Editor-in-Chief

ISSN (Print): 1573-4056
ISSN (Online): 1875-6603

Research Article

Multisite Percutaneous Bone Augmentation for the Treatment of Acetabular Osteolytic Metastases Involving the Articular Surfaces: A Randomised Trial

Author(s): Weiming Ge, Xunwei Liu, Mingzhen Liu and Wenkun Zhuo*

Volume 20, 2024

Published on: 12 May, 2023

Article ID: e280323215024 Pages: 7

DOI: 10.2174/1573405620666230328083639

open_access

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Abstract

Introduction: For patients with acetabular osteolytic metastases involving the articular surfaces, current treatments cannot efficiently rebuild the acetabular bone frame structure and strengthen bone defect area mechanics for weight-bearing. The purpose of this study is to show the operational procedure and clinical outcomes of multisite percutaneous bone augmentation (PBA) for the treatment of incidental acetabular osteolytic metastases involving the articular surfaces.

Methods: According to the inclusion and exclusion criteria, 8 patients (4 males and 4 females) were included in this study. Multisite (3 or 4 sites) PBA was successfully performed in all patients. The pain and function evaluation and imaging observation were examined by VAS and Harris hip joint function scores at the different time points (pre-procedure, 7 days, one month, last follow-up in 5-20 months).

Results: There were significant differences (p<0.05) in VAS and Harris scores before and after the surgical procedure. Moreover, these two scores had no obvious changes during the follow-up process (7 days after the procedure, one month after the procedure, and the last follow-up) after the procedure.

Conclusion: The proposed multisite PBA is an effective and safe procedure for the treatment of acetabular osteolytic metastases involving the articular surfaces.

Keywords: Acetabular osteolytic metastases, Articular surfaces, Bone frame structure reconstruction, Clinical outcomes, Multisite percutaneous bone augmentation, PBA.

[1]
Mundy GR. Metastasis to bone: Causes, consequences and therapeutic opportunities. Nat Rev Cancer 2002; 2(8): 584-93.
[http://dx.doi.org/10.1038/nrc867] [PMID: 12154351]
[2]
Aubry S, Dubut J, Nueffer JP, Chaigneau L, Vidal C, Kastler B. Prospective 1-year follow-up pilot study of CT-guided microwave ablation in the treatment of bone and soft-tissue malignant tumours. Eur Radiol 2017; 27(4): 1477-85.
[http://dx.doi.org/10.1007/s00330-016-4528-7] [PMID: 27553929]
[3]
Cotten A, Duquesnoy B. Percutaneous cementoplasty for malignant osteolysis of the acetabulum. Presse Med 1995; 24(28): 1308-10.
[PMID: 7501624]
[4]
Sun G, Jin P, Liu X, Li M, Li L. Cementoplasty for managing painful bone metastases outside the spine. Eur Radiol 2014; 24(3): 731-7.
[http://dx.doi.org/10.1007/s00330-013-3071-z] [PMID: 24272227]
[5]
Charles T, Ameye L, Gebhart M. Surgical treatment for periacetabular metastatic lesions. Eur J Surg Oncol 2017; 43(9): 1727-32.
[http://dx.doi.org/10.1016/j.ejso.2017.03.018] [PMID: 28483275]
[6]
Fuchs B, Hoekzema N, Larson DR, Inwards CY, Sim FH. Osteosarcoma of the pelvis: Outcome analysis of surgical treatment. Clin Orthop Relat Res 2009; 467(2): 510-8.
[http://dx.doi.org/10.1007/s11999-008-0495-x] [PMID: 18855090]
[7]
Krishnan CK, Han I, Kim HS. Outcome after surgery for metastases to the pelvic bone: A single institutional experience. Clin Orthop Surg 2017; 9(1): 116-25.
[http://dx.doi.org/10.4055/cios.2017.9.1.116] [PMID: 28261437]
[8]
Puget J, Utheza G. Reconstruction of the iliac bone using the homolateral femur after resection for pelvic tumor. Orthop Traumatol Surg Res 2014; 100(1): 43-7.
[http://dx.doi.org/10.1016/j.otsr.2013.12.007] [PMID: 24440547]
[9]
Barghash RF, Abdou WM. Pathophysiology of metastatic bone disease and the role of the second generation of bisphosphonates: From basic science to medicine. Curr Pharm Des 2016; 22(11): 1546-57.
[http://dx.doi.org/10.2174/1381612822666160122093810] [PMID: 26795564]
[10]
Mehrotra B. Antiresorptive therapies for the treatment of malignant osteolytic bone disease. Oral Maxillofac Surg Clin North Am 2015; 27(4): 561-6.
[http://dx.doi.org/10.1016/j.coms.2015.07.002] [PMID: 26515737]
[11]
Okuda H, Sugiura H, Yamada K, Hayashi N, Soga N, Ogura Y. Effect of radiotherapy and bisphosphonate on bone metastases from renal cell carcinoma. Gan To Kagaku Ryoho 2013; 40(11): 1497-501.
[PMID: 24231702]
[12]
Harty JA, Brennan D, Eustace S, O’Byrne J. Percutaneous cementoplasty of acetabular bony metastasis. Surgeon 2003; 1(1): 48-50.
[http://dx.doi.org/10.1016/S1479-666X(03)80010-0] [PMID: 15568426]
[13]
Harris K, Pugash R, David E, et al. Percutaneous cementoplasty of lytic metastasis in left acetabulum. Curr Oncol 2007; 14(1): 4-8.
[http://dx.doi.org/10.3747/co.2007.95] [PMID: 17576457]
[14]
Sun G, Wei D, Liu X, et al. Novel biodegradable electrospun nanofibrous P(DLLA-CL) balloons for the treatment of vertebral compression fractures. Nanomedicine 2013; 9(6): 829-38.
[http://dx.doi.org/10.1016/j.nano.2012.12.003] [PMID: 23318398]
[15]
Cline M, Herman J, Shaw ER, Morton RD. Standardization of the visual analogue scale. Nurs Res 1992; 41(6): 378-9.
[http://dx.doi.org/10.1097/00006199-199211000-00013] [PMID: 1437591]
[16]
Singh JA, Schleck C, Harmsen S, Lewallen D. Clinically important improvement thresholds for Harris Hip Score and its ability to predict revision risk after primary total hip arthroplasty. BMC Musculoskelet Disord 2016; 17(1): 256.
[http://dx.doi.org/10.1186/s12891-016-1106-8] [PMID: 27286675]
[17]
Radvany MG, Murphy KJ, Millward SF, et al. Research reporting standards for percutaneous vertebral augmentation. J Vasc Interv Radiol 2009; 20(10): 1279-86.
[http://dx.doi.org/10.1016/j.jvir.2009.07.030] [PMID: 19800540]
[18]
Michel JP, Klopfenstein C, Hoffmeyer P, Stern R, Grab B. Hip fracture surgery: Is the pre-operative American Society of Anesthesiologists (ASA) score a predictor of functional outcome? Aging Clin Exp Res 2002; 14(5): 389-94.
[http://dx.doi.org/10.1007/BF03324467] [PMID: 12602574]
[19]
Zhang R, Yin Y, Li A, et al. Three-column classification for acetabular fractures: Introduction and reproducibility assessment. J Bone Joint Surg Am 2019; 101(22): 2015-25.
[http://dx.doi.org/10.2106/JBJS.19.00284] [PMID: 31764364]
[20]
Liu X, Jin P, Liu K, et al. Comparison of percutaneous long bone cementoplasty with or without embedding a cement-filled catheter for painful long bone metastases with impending fracture. Eur Radiol 2017; 27(1): 120-7.
[http://dx.doi.org/10.1007/s00330-016-4347-x] [PMID: 27097791]
[21]
Li Z, Butala NB, Etheridge BS, Siegel HJ, Lemons JE, Eberhardt AW. A biomechanical study of periacetabular defects and cement filling. J Biomech Eng 2007; 129(2): 129-36.
[http://dx.doi.org/10.1115/1.2472367] [PMID: 17408317]

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